Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study
Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesion...
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MDPI AG
2021-08-01
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| Series: | Cancers |
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| author | Hisaki Aiba Kunihiro Ikuta Kunihiro Asanuma Katsuhisa Kawanami Satoshi Tsukushi Akihiko Matsumine Daisuke Ishimura Akihito Nagano Yoji Shido Eiji Kozawa Kenji Yamada Junji Wasa Hiroaki Kimura Takao Sakai Hideki Murakami Tomohisa Sakai Tomoki Nakamura Yoshihiro Nishida |
| author_facet | Hisaki Aiba Kunihiro Ikuta Kunihiro Asanuma Katsuhisa Kawanami Satoshi Tsukushi Akihiko Matsumine Daisuke Ishimura Akihito Nagano Yoji Shido Eiji Kozawa Kenji Yamada Junji Wasa Hiroaki Kimura Takao Sakai Hideki Murakami Tomohisa Sakai Tomoki Nakamura Yoshihiro Nishida |
| author_sort | Hisaki Aiba |
| collection | DOAJ |
| description | Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesions treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. The effect of neoadjuvant therapy on the tail sign was investigated by analyzing the change in tail-like lesions during neoadjuvant therapy and histological responses. The median length of the tail-like lesion reduced from 29.5 mm at initiation to 19.5 mm after neoadjuvant therapy. The extent of shrinkage in tail-like lesions was related to the histopathological responses in the main part of the tumor. Complete disappearance of the tail-like lesion was observed in 12 patients; however, it was not related to achieving a microscopically negative margin. The oncologic outcomes did not significantly differ between cases with and without the complete disappearance of tail-like lesions. This study indicated that the shrinkage of tail-like lesions did not have a significant effect on complete resection or improvements of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgical strategy. |
| first_indexed | 2024-03-10T09:16:38Z |
| format | Article |
| id | doaj.art-013dfc726d054367aece85e492a3564b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:16:38Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-013dfc726d054367aece85e492a3564b2023-11-22T05:29:45ZengMDPI AGCancers2072-66942021-08-011315390110.3390/cancers13153901Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective StudyHisaki Aiba0Kunihiro Ikuta1Kunihiro Asanuma2Katsuhisa Kawanami3Satoshi Tsukushi4Akihiko Matsumine5Daisuke Ishimura6Akihito Nagano7Yoji Shido8Eiji Kozawa9Kenji Yamada10Junji Wasa11Hiroaki Kimura12Takao Sakai13Hideki Murakami14Tomohisa Sakai15Tomoki Nakamura16Yoshihiro Nishida17Department of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8570, JapanDepartment of Orthopaedic Surgery, Aichi Medical University School of Medicine, Nagakute 480-1195, JapanDivision of Orthopaedic Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, JapanDepartment of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences University of Fukui, Fukui 910-1193, JapanDepartment of Orthopaedic Surgery, Fujita Medical University, Toyoake 470-1192, JapanDepartment of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Orthopaedic Surgery, Hamamatsu Medical University, Hamamatsu 431-3125, JapanDepartment of Orthopaedic Surgery, Nagoya Memorial Hospital, Nagoya 468-8250, JapanDepartment of Orthopedic Oncology, Okazaki City Hospital, Okazaki 444-8553, JapanDivision of Orthopaedic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi 411-0934, JapanDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Orthopedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, JapanDepartment of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu 514-8570, JapanDepartment of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, JapanSeveral types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy of neoadjuvant therapy for tumors with tail-like lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients with soft tissue sarcoma with tail-like lesions treated with neoadjuvant therapy, including chemotherapy, radiotherapy, or both. The effect of neoadjuvant therapy on the tail sign was investigated by analyzing the change in tail-like lesions during neoadjuvant therapy and histological responses. The median length of the tail-like lesion reduced from 29.5 mm at initiation to 19.5 mm after neoadjuvant therapy. The extent of shrinkage in tail-like lesions was related to the histopathological responses in the main part of the tumor. Complete disappearance of the tail-like lesion was observed in 12 patients; however, it was not related to achieving a microscopically negative margin. The oncologic outcomes did not significantly differ between cases with and without the complete disappearance of tail-like lesions. This study indicated that the shrinkage of tail-like lesions did not have a significant effect on complete resection or improvements of clinical outcomes. A more comprehensive evaluation is needed to elaborate on the surgical strategy.https://www.mdpi.com/2072-6694/13/15/3901soft tissue sarcomainvasive fronttail-like lesionmyxofibrosarcomaundifferentiated pleomorphic sarcomaneoadjuvant therapy |
| spellingShingle | Hisaki Aiba Kunihiro Ikuta Kunihiro Asanuma Katsuhisa Kawanami Satoshi Tsukushi Akihiko Matsumine Daisuke Ishimura Akihito Nagano Yoji Shido Eiji Kozawa Kenji Yamada Junji Wasa Hiroaki Kimura Takao Sakai Hideki Murakami Tomohisa Sakai Tomoki Nakamura Yoshihiro Nishida Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study Cancers soft tissue sarcoma invasive front tail-like lesion myxofibrosarcoma undifferentiated pleomorphic sarcoma neoadjuvant therapy |
| title | Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study |
| title_full | Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study |
| title_fullStr | Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study |
| title_full_unstemmed | Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study |
| title_short | Effect of Neoadjuvant Therapies on Soft Tissue Sarcomas with Tail-like Lesions: A Multicenter Retrospective Study |
| title_sort | effect of neoadjuvant therapies on soft tissue sarcomas with tail like lesions a multicenter retrospective study |
| topic | soft tissue sarcoma invasive front tail-like lesion myxofibrosarcoma undifferentiated pleomorphic sarcoma neoadjuvant therapy |
| url | https://www.mdpi.com/2072-6694/13/15/3901 |
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