Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis
Abstract Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used in select cases with heparin‐induced thrombocytopenia (HIT). In a cross‐sectional analysis, a propensity matched sample was generated by IVIG or TPE treatment status to assess the primary outcome of mortality....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.211 |
| _version_ | 1797740005285691392 |
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| author | Alexandre Soares Ferreira Júnior Stephen H. Boyle Maragatha Kuchibhatla Oluwatoyosi A. Onwuemene |
| author_facet | Alexandre Soares Ferreira Júnior Stephen H. Boyle Maragatha Kuchibhatla Oluwatoyosi A. Onwuemene |
| author_sort | Alexandre Soares Ferreira Júnior |
| collection | DOAJ |
| description | Abstract Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used in select cases with heparin‐induced thrombocytopenia (HIT). In a cross‐sectional analysis, a propensity matched sample was generated by IVIG or TPE treatment status to assess the primary outcome of mortality. In 500 HIT cases, IVIG or TPE was not associated with increased mortality (OR = 1.46; 95% CI: 0.81–2.63, p = 0.2052) but was associated with a higher likelihood of major bleeding (OR = 1.75; 95% CI: 1.03–2.96, p = 0.0376). The use of IVIG or TPE in HIT cases with bleeding contraindications to standard therapies should be further investigated. |
| first_indexed | 2024-03-12T14:05:21Z |
| format | Article |
| id | doaj.art-013f1f85632e407c9aa8b93285d99094 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-12T14:05:21Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-013f1f85632e407c9aa8b93285d990942023-08-21T14:10:34ZengWileyeJHaem2688-61462021-08-012346647010.1002/jha2.211Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysisAlexandre Soares Ferreira Júnior0Stephen H. Boyle1Maragatha Kuchibhatla2Oluwatoyosi A. Onwuemene3School of Medicine Barretos School of Health Sciences Dr. Paulo Prata Barretos São Paulo BrazilDuke University School of Medicine Durham North Carolina USADepartment of Biostatistics and Bioinformatics Duke University School of Medicine Durham North Carolina USADivision of Hematology Department of Medicine Duke University School of Medicine Durham North Carolina USAAbstract Intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE) are used in select cases with heparin‐induced thrombocytopenia (HIT). In a cross‐sectional analysis, a propensity matched sample was generated by IVIG or TPE treatment status to assess the primary outcome of mortality. In 500 HIT cases, IVIG or TPE was not associated with increased mortality (OR = 1.46; 95% CI: 0.81–2.63, p = 0.2052) but was associated with a higher likelihood of major bleeding (OR = 1.75; 95% CI: 1.03–2.96, p = 0.0376). The use of IVIG or TPE in HIT cases with bleeding contraindications to standard therapies should be further investigated.https://doi.org/10.1002/jha2.211heparin‐induced thrombocytopeniaintravenous immune globulinNational Inpatient Sampletherapeutic plasma exchange |
| spellingShingle | Alexandre Soares Ferreira Júnior Stephen H. Boyle Maragatha Kuchibhatla Oluwatoyosi A. Onwuemene Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis eJHaem heparin‐induced thrombocytopenia intravenous immune globulin National Inpatient Sample therapeutic plasma exchange |
| title | Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis |
| title_full | Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis |
| title_fullStr | Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis |
| title_full_unstemmed | Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis |
| title_short | Bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin‐induced thrombocytopenia: A propensity matched analysis |
| title_sort | bleeding is associated with intravenous immunoglobulin and therapeutic plasma exchange use in heparin induced thrombocytopenia a propensity matched analysis |
| topic | heparin‐induced thrombocytopenia intravenous immune globulin National Inpatient Sample therapeutic plasma exchange |
| url | https://doi.org/10.1002/jha2.211 |
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