RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor m...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21514-8 |
| _version_ | 1818399351978852352 |
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| author | Huilong Yin Xiang Zhang Pengyuan Yang Xiaofang Zhang Yingran Peng Da Li Yanping Yu Ye Wu Yidi Wang Jinbao Zhang Xiaochen Ding Xiangpeng Wang Angang Yang Rui Zhang |
| author_facet | Huilong Yin Xiang Zhang Pengyuan Yang Xiaofang Zhang Yingran Peng Da Li Yanping Yu Ye Wu Yidi Wang Jinbao Zhang Xiaochen Ding Xiangpeng Wang Angang Yang Rui Zhang |
| author_sort | Huilong Yin |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor models, influencing macrophage reprogramming and attenuating PD-1 blockade. |
| first_indexed | 2024-12-14T07:19:18Z |
| format | Article |
| id | doaj.art-013f4347490a418eb0ba0440e7fbe53f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:19:18Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-013f4347490a418eb0ba0440e7fbe53f2022-12-21T23:11:38ZengNature PortfolioNature Communications2041-17232021-03-0112111510.1038/s41467-021-21514-8RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogrammingHuilong Yin0Xiang Zhang1Pengyuan Yang2Xiaofang Zhang3Yingran Peng4Da Li5Yanping Yu6Ye Wu7Yidi Wang8Jinbao Zhang9Xiaochen Ding10Xiangpeng Wang11Angang Yang12Rui Zhang13The State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical UniversityThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical UniversityKey Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, University of Chinese Academy of Sciences, Chinese Academy of SciencesThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical UniversityThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical UniversityThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical UniversityThe Second Ward of Gynecological Tumor, Shaanxi Provincial Tumor HospitalThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical UniversityDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical UniversityThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical UniversityDepartment of Experimental Surgery, Xijing Hospital, Fourth Military Medical UniversityHenan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical UniversityThe State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical UniversityThe State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical UniversityN6-methyladenosine (m6A) is a reversible mRNA modification with important roles in cancer biology and immunoregulation. Here, the authors show that myeloid-specific deletion of Mettl3, the catalytic subunit of the methyltransferase complex, promotes tumor growth and metastasis in preclinical tumor models, influencing macrophage reprogramming and attenuating PD-1 blockade.https://doi.org/10.1038/s41467-021-21514-8 |
| spellingShingle | Huilong Yin Xiang Zhang Pengyuan Yang Xiaofang Zhang Yingran Peng Da Li Yanping Yu Ye Wu Yidi Wang Jinbao Zhang Xiaochen Ding Xiangpeng Wang Angang Yang Rui Zhang RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming Nature Communications |
| title | RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming |
| title_full | RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming |
| title_fullStr | RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming |
| title_full_unstemmed | RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming |
| title_short | RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming |
| title_sort | rna m6a methylation orchestrates cancer growth and metastasis via macrophage reprogramming |
| url | https://doi.org/10.1038/s41467-021-21514-8 |
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