Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions
Alterations in cardiac function were observed in antidepressants treated patients and published in several clinical reports. These detected changes could be either a consequence of the treatment or of depression itself, which has already been proved to be a risk factor in heart diseases. In order to...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2012-12-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400023&lng=en&tlng=en |
| _version_ | 1818357712055959552 |
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| author | Natasa Spasojevic Predrag Jovanovic Sladjana Dronjak |
| author_facet | Natasa Spasojevic Predrag Jovanovic Sladjana Dronjak |
| author_sort | Natasa Spasojevic |
| collection | DOAJ |
| description | Alterations in cardiac function were observed in antidepressants treated patients and published in several clinical reports. These detected changes could be either a consequence of the treatment or of depression itself, which has already been proved to be a risk factor in heart diseases. In order to determine a possible influence of chronic treatment with norepinephrinergic reuptake inhibitor, maprotiline, on the heart, we investigated gene expression of cardiac β-adrenoceptors both in controls and in animals with signs of depression. The rats were divided into two groups, unstressed controls and those exposed to chronic unpredictable mild stress (CUMS). The groups were further divided into two subgroups, one receiving daily intraperitoneal injections of vehicle (sterile water) and another one maprotiline (10 mg/kg) for four weeks. Tissue samples were collected after the last application. Gene expression of cardiac β1- and β2-adrenoceptor was determined using Real-time RT-PCR analysis. Our results show that in control animals expression of both adrenoreceptors was decreased in the right atria after 4 weeks of maprotiline application. Contrary, the same treatment led to a significant increase in expression of cardiac β1-adrenoceptor in the stressed rats, with no change in the characteristics of β2-adrenoceptor. Our findings might reflect the that molecular mechanisms are underlying factors involved in the development of cardiovascular diseases linked with antidepressant treatment. |
| first_indexed | 2024-12-13T20:17:28Z |
| format | Article |
| id | doaj.art-0141189a85fc48d38f195f5f235b5115 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T20:17:28Z |
| publishDate | 2012-12-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-0141189a85fc48d38f195f5f235b51152022-12-21T23:32:46ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902012-12-0148479379910.1590/S1984-82502012000400023S1984-82502012000400023Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditionsNatasa Spasojevic0Predrag Jovanovic1Sladjana Dronjak2University of BelgradeUniversity of BelgradeUniversity of BelgradeAlterations in cardiac function were observed in antidepressants treated patients and published in several clinical reports. These detected changes could be either a consequence of the treatment or of depression itself, which has already been proved to be a risk factor in heart diseases. In order to determine a possible influence of chronic treatment with norepinephrinergic reuptake inhibitor, maprotiline, on the heart, we investigated gene expression of cardiac β-adrenoceptors both in controls and in animals with signs of depression. The rats were divided into two groups, unstressed controls and those exposed to chronic unpredictable mild stress (CUMS). The groups were further divided into two subgroups, one receiving daily intraperitoneal injections of vehicle (sterile water) and another one maprotiline (10 mg/kg) for four weeks. Tissue samples were collected after the last application. Gene expression of cardiac β1- and β2-adrenoceptor was determined using Real-time RT-PCR analysis. Our results show that in control animals expression of both adrenoreceptors was decreased in the right atria after 4 weeks of maprotiline application. Contrary, the same treatment led to a significant increase in expression of cardiac β1-adrenoceptor in the stressed rats, with no change in the characteristics of β2-adrenoceptor. Our findings might reflect the that molecular mechanisms are underlying factors involved in the development of cardiovascular diseases linked with antidepressant treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400023&lng=en&tlng=enAntidepressivosDepressãoDoenças cardiovascularesReceptores ß-adrenérgicos cardíacos |
| spellingShingle | Natasa Spasojevic Predrag Jovanovic Sladjana Dronjak Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions Brazilian Journal of Pharmaceutical Sciences Antidepressivos Depressão Doenças cardiovasculares Receptores ß-adrenérgicos cardíacos |
| title | Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions |
| title_full | Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions |
| title_fullStr | Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions |
| title_full_unstemmed | Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions |
| title_short | Maprotiline treatment differentially influences cardiac β-adrenoreceptors expression under normal and stress conditions |
| title_sort | maprotiline treatment differentially influences cardiac β adrenoreceptors expression under normal and stress conditions |
| topic | Antidepressivos Depressão Doenças cardiovasculares Receptores ß-adrenérgicos cardíacos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400023&lng=en&tlng=en |
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