The airway neuro-immune axis as a therapeutic target in allergic airway diseases
Abstract Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma and allergic rhinitis. The intimate spatial relationship between neurons and immune cells suggests that their interactions play a pivotal role...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-024-02702-8 |
| _version_ | 1797273502850482176 |
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| author | Wanhua Wu Jianing Li Su Chen Suidong Ouyang |
| author_facet | Wanhua Wu Jianing Li Su Chen Suidong Ouyang |
| author_sort | Wanhua Wu |
| collection | DOAJ |
| description | Abstract Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma and allergic rhinitis. The intimate spatial relationship between neurons and immune cells suggests that their interactions play a pivotal role in regulating allergic airway inflammation. Upon direct activation by allergens, neurons and immune cells engage in interactions, during which neurotransmitters and neuropeptides released by neurons modulate immune cell activity. Meanwhile, immune cells release inflammatory mediators such as histamine and cytokines, stimulating neurons and amplifying neuropeptide production, thereby exacerbating allergic inflammation. The dynamic interplay between the nervous and immune systems suggests that targeting the neuro-immune axis in the airway could represent a novel approach to treating allergic airway diseases. This review summarized recent evidence on the nervous system’s regulatory mechanisms in immune responses and identified potential therapeutic targets along the peripheral nerve-immune axis for allergic asthma and allergic rhinitis. The findings will provide novel perspectives on the management of allergic airway diseases in the future. |
| first_indexed | 2024-03-07T14:45:18Z |
| format | Article |
| id | doaj.art-014166fa635848e8ae831a49c93b37fe |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-03-07T14:45:18Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-014166fa635848e8ae831a49c93b37fe2024-03-05T20:02:16ZengBMCRespiratory Research1465-993X2024-02-012511910.1186/s12931-024-02702-8The airway neuro-immune axis as a therapeutic target in allergic airway diseasesWanhua Wu0Jianing Li1Su Chen2Suidong Ouyang3Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, College of Medical Technology, Guangdong Medical UniversityGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, College of Medical Technology, Guangdong Medical UniversityLiaobu Hospital of Dongguan CityGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, College of Medical Technology, Guangdong Medical UniversityAbstract Recent evidence has increasingly underscored the importance of the neuro-immune axis in mediating allergic airway diseases, such as allergic asthma and allergic rhinitis. The intimate spatial relationship between neurons and immune cells suggests that their interactions play a pivotal role in regulating allergic airway inflammation. Upon direct activation by allergens, neurons and immune cells engage in interactions, during which neurotransmitters and neuropeptides released by neurons modulate immune cell activity. Meanwhile, immune cells release inflammatory mediators such as histamine and cytokines, stimulating neurons and amplifying neuropeptide production, thereby exacerbating allergic inflammation. The dynamic interplay between the nervous and immune systems suggests that targeting the neuro-immune axis in the airway could represent a novel approach to treating allergic airway diseases. This review summarized recent evidence on the nervous system’s regulatory mechanisms in immune responses and identified potential therapeutic targets along the peripheral nerve-immune axis for allergic asthma and allergic rhinitis. The findings will provide novel perspectives on the management of allergic airway diseases in the future.https://doi.org/10.1186/s12931-024-02702-8Airway neuro-immune axisTherapeutic targetAsthmaAllergic rhinitis |
| spellingShingle | Wanhua Wu Jianing Li Su Chen Suidong Ouyang The airway neuro-immune axis as a therapeutic target in allergic airway diseases Respiratory Research Airway neuro-immune axis Therapeutic target Asthma Allergic rhinitis |
| title | The airway neuro-immune axis as a therapeutic target in allergic airway diseases |
| title_full | The airway neuro-immune axis as a therapeutic target in allergic airway diseases |
| title_fullStr | The airway neuro-immune axis as a therapeutic target in allergic airway diseases |
| title_full_unstemmed | The airway neuro-immune axis as a therapeutic target in allergic airway diseases |
| title_short | The airway neuro-immune axis as a therapeutic target in allergic airway diseases |
| title_sort | airway neuro immune axis as a therapeutic target in allergic airway diseases |
| topic | Airway neuro-immune axis Therapeutic target Asthma Allergic rhinitis |
| url | https://doi.org/10.1186/s12931-024-02702-8 |
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