A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers
Abstract Neuroticism is a basic personality trait concerning negative feelings under stressful conditions. Our purpose was to examine the rate of high neuroticism and factors associated with high neuroticism in long-term (≥ 5 years) survivors of childhood, adolescent, and young adult cancer (CAYACSs...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15697-3 |
| _version_ | 1828260259824664576 |
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| author | Alv A. Dahl Cecilie Essholt Kiserud Sophie D. Fosså Jon Håvard Loge Kristin Valborg Reinertsen Ellen Ruud Hanne C. Lie |
| author_facet | Alv A. Dahl Cecilie Essholt Kiserud Sophie D. Fosså Jon Håvard Loge Kristin Valborg Reinertsen Ellen Ruud Hanne C. Lie |
| author_sort | Alv A. Dahl |
| collection | DOAJ |
| description | Abstract Neuroticism is a basic personality trait concerning negative feelings under stressful conditions. Our purpose was to examine the rate of high neuroticism and factors associated with high neuroticism in long-term (≥ 5 years) survivors of childhood, adolescent, and young adult cancer (CAYACSs). Norwegian CAYACSs aged 0–39 years when diagnosed and treated between 1985 and 2009 for cancer in childhood/adolescence (0–18 years), or as young adults (19–39 years) and alive in 2015 were mailed a questionnaire. Data from 1629 CAYACSs (481 children/adolescents and 1148 young adults) were analyzed. High neuroticism was found in 44% of survivors of childhood/adolescent cancers versus 34% in survivors of young adult cancer (p < 0.001). The rate of high neuroticism in female CAYACSs was 40% and in males 30% (p < 0.001). The corresponding difference between male survivor group was non-significant. In multivariable analysis, young age at survey, more adverse effects, poor self-rated health, female sex, chronic fatigue, and increased depression remained significantly associated with high neuroticism. Cancer treatment, comorbidity, and lifestyle were significant in bivariate analyses. Cancer at earlier age could increase the risk of high neuroticism among adult survivors. Screening for neuroticism could identify CAYACSs at risk for experiencing multiple health concerns and needing special follow-up attention. |
| first_indexed | 2024-04-13T03:20:52Z |
| format | Article |
| id | doaj.art-014482ebcf23401cb449711942214b69 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T03:20:52Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-014482ebcf23401cb449711942214b692022-12-22T03:04:47ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-15697-3A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancersAlv A. Dahl0Cecilie Essholt Kiserud1Sophie D. Fosså2Jon Håvard Loge3Kristin Valborg Reinertsen4Ellen Ruud5Hanne C. Lie6National Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, RadiumhospitaletNational Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, RadiumhospitaletNational Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, RadiumhospitaletDepartment of Oncology, Oslo University HospitalNational Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, RadiumhospitaletDepartment of Behavioural Medicine, Institute of Basic Medical Sciences, University of OsloNational Resource Center for Late Effects After Cancer Treatment, Oslo University Hospital, RadiumhospitaletAbstract Neuroticism is a basic personality trait concerning negative feelings under stressful conditions. Our purpose was to examine the rate of high neuroticism and factors associated with high neuroticism in long-term (≥ 5 years) survivors of childhood, adolescent, and young adult cancer (CAYACSs). Norwegian CAYACSs aged 0–39 years when diagnosed and treated between 1985 and 2009 for cancer in childhood/adolescence (0–18 years), or as young adults (19–39 years) and alive in 2015 were mailed a questionnaire. Data from 1629 CAYACSs (481 children/adolescents and 1148 young adults) were analyzed. High neuroticism was found in 44% of survivors of childhood/adolescent cancers versus 34% in survivors of young adult cancer (p < 0.001). The rate of high neuroticism in female CAYACSs was 40% and in males 30% (p < 0.001). The corresponding difference between male survivor group was non-significant. In multivariable analysis, young age at survey, more adverse effects, poor self-rated health, female sex, chronic fatigue, and increased depression remained significantly associated with high neuroticism. Cancer treatment, comorbidity, and lifestyle were significant in bivariate analyses. Cancer at earlier age could increase the risk of high neuroticism among adult survivors. Screening for neuroticism could identify CAYACSs at risk for experiencing multiple health concerns and needing special follow-up attention.https://doi.org/10.1038/s41598-022-15697-3 |
| spellingShingle | Alv A. Dahl Cecilie Essholt Kiserud Sophie D. Fosså Jon Håvard Loge Kristin Valborg Reinertsen Ellen Ruud Hanne C. Lie A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers Scientific Reports |
| title | A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers |
| title_full | A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers |
| title_fullStr | A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers |
| title_full_unstemmed | A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers |
| title_short | A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers |
| title_sort | study of high neuroticism in long term survivors of childhood adolescence and young adult cancers |
| url | https://doi.org/10.1038/s41598-022-15697-3 |
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