Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma
Objective: to study the state of cellular immunity in patients with gastric adenocarcinoma.Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage I–III, 20 with stage IV) received surgical / combined treatment or independent chemotherapy...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-03-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/256 |
| _version_ | 1797696802990850048 |
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| author | G. G. Khakimova T. N. Zabotina A. A. Tryakin A. A. Borunova T. V. Davidova A. E. Kalinin Yu. V. Vakhabova E. N. Zakharova D. V. Tabakov |
| author_facet | G. G. Khakimova T. N. Zabotina A. A. Tryakin A. A. Borunova T. V. Davidova A. E. Kalinin Yu. V. Vakhabova E. N. Zakharova D. V. Tabakov |
| author_sort | G. G. Khakimova |
| collection | DOAJ |
| description | Objective: to study the state of cellular immunity in patients with gastric adenocarcinoma.Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage I–III, 20 with stage IV) received surgical / combined treatment or independent chemotherapy, respectively, at the N. N. Blokhin National Medical ResearchCenter of Oncology. Peripheral blood sampling was carried out before starting treatment. We studied the cellular composition of peripheral blood, as well as systemic immunity parameters determined by flow cytometry (CD3+CD4+; CD3+CD8+; CD4+CD8+; CD4+/CD8+; CD3–CD16+CD56+; CD3–CD19+), and their prognostic significance in relation to overall survival and progression-free survival.Results. The prognostic value of the relative indicator of platelet lymphocytic index was determined: progression-free survival in patients with a high level of platelet-lymphocytic index (>208.7) was higher: 8.1 months versus 4.5 months (p = 0.0027). A favorable prognosis for overall survival was an increase in the number of CD3–CD19+ lymphocytes (hazard ratio (HR) 0.91; 95 % confidence interval (CI) 0.85–0.97; p = 0.007), and an unfavorable prognosis was an increase in the number of neutrophils (HR 1.26; 95 % CI 1.05–1.50; p = 0.012), platelet count (HR 1.01; 95 % CI 1.0–1.01; p = 0.043), as well as an increase in the number of NK cells (HR 1.04, 95 % CI 1.0–1.09; p = 0.029).Conclusion. Indicators of the cellular composition of peripheral blood, characterizing a systemic inflammatory reaction, as well as indicators of systemic immunity, can serve as additional prognostic factors for gastric cancer. |
| first_indexed | 2024-03-12T03:31:25Z |
| format | Article |
| id | doaj.art-0144ea3898ec419baab53385814d0f07 |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2024-03-12T03:31:25Z |
| publishDate | 2020-03-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-0144ea3898ec419baab53385814d0f072023-09-03T13:24:40ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872020-03-0171384610.17650/2313-805X-2020-7-1-38-46181Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinomaG. G. Khakimova0T. N. Zabotina1A. A. Tryakin2A. A. Borunova3T. V. Davidova4A. E. Kalinin5Yu. V. Vakhabova6E. N. Zakharova7D. V. Tabakov8ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииObjective: to study the state of cellular immunity in patients with gastric adenocarcinoma.Materials and methods. From 2017 to 2018, 45 previously untreated patients with gastric adenocarcinoma (25 with stage I–III, 20 with stage IV) received surgical / combined treatment or independent chemotherapy, respectively, at the N. N. Blokhin National Medical ResearchCenter of Oncology. Peripheral blood sampling was carried out before starting treatment. We studied the cellular composition of peripheral blood, as well as systemic immunity parameters determined by flow cytometry (CD3+CD4+; CD3+CD8+; CD4+CD8+; CD4+/CD8+; CD3–CD16+CD56+; CD3–CD19+), and their prognostic significance in relation to overall survival and progression-free survival.Results. The prognostic value of the relative indicator of platelet lymphocytic index was determined: progression-free survival in patients with a high level of platelet-lymphocytic index (>208.7) was higher: 8.1 months versus 4.5 months (p = 0.0027). A favorable prognosis for overall survival was an increase in the number of CD3–CD19+ lymphocytes (hazard ratio (HR) 0.91; 95 % confidence interval (CI) 0.85–0.97; p = 0.007), and an unfavorable prognosis was an increase in the number of neutrophils (HR 1.26; 95 % CI 1.05–1.50; p = 0.012), platelet count (HR 1.01; 95 % CI 1.0–1.01; p = 0.043), as well as an increase in the number of NK cells (HR 1.04, 95 % CI 1.0–1.09; p = 0.029).Conclusion. Indicators of the cellular composition of peripheral blood, characterizing a systemic inflammatory reaction, as well as indicators of systemic immunity, can serve as additional prognostic factors for gastric cancer.https://umo.abvpress.ru/jour/article/view/256аденокарцинома желудкаклеточный иммунитетсубпопуляция лимфоцитовнейтрофильно-лимфоцитраный индекстромбоцитарно-лимфоцитарный индекс |
| spellingShingle | G. G. Khakimova T. N. Zabotina A. A. Tryakin A. A. Borunova T. V. Davidova A. E. Kalinin Yu. V. Vakhabova E. N. Zakharova D. V. Tabakov Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma Успехи молекулярной онкологии аденокарцинома желудка клеточный иммунитет субпопуляция лимфоцитов нейтрофильно-лимфоцитраный индекс тромбоцитарно-лимфоцитарный индекс |
| title | Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma |
| title_full | Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma |
| title_fullStr | Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma |
| title_full_unstemmed | Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma |
| title_short | Analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma |
| title_sort | analysis of systemic immunity and inflammation in the prognosis of gastric adenocarcinoma |
| topic | аденокарцинома желудка клеточный иммунитет субпопуляция лимфоцитов нейтрофильно-лимфоцитраный индекс тромбоцитарно-лимфоцитарный индекс |
| url | https://umo.abvpress.ru/jour/article/view/256 |
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