Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
Colorectal cancer (CRC) is a common malignant tumor with a high frequency of recurrence and metastasis, which are the major causes of death in patients. The prerequisite for the invasion and metastasis is the strong mobility of CRC cells to transport far away from the original site to the distant or...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/12/1723 |
| _version_ | 1797461257369944064 |
|---|---|
| author | Zhuomin Tan Wenyan Sun Ya Li Xingmeng Jiao Mingliang Zhu Junfei Zhang Chen Qing Yinnong Jia |
| author_facet | Zhuomin Tan Wenyan Sun Ya Li Xingmeng Jiao Mingliang Zhu Junfei Zhang Chen Qing Yinnong Jia |
| author_sort | Zhuomin Tan |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common malignant tumor with a high frequency of recurrence and metastasis, which are the major causes of death in patients. The prerequisite for the invasion and metastasis is the strong mobility of CRC cells to transport far away from the original site to the distant organs and tissues, where they settle down and proliferate. It was reported that the epithelial-mesenchymal transition (EMT) is involved in the occurrence and development of various tumors in the entire process of tumor invasion and metastasis. Therefore, as a vital factor for the biological characteristics of tumor cells, EMT markers may serve as prognostic predictors and potential therapeutic targets in CRC. This article mainly reviews the current status of CRC with metastasis, the studies of EMT, the possible relationship of EMT with CRC, as well as the potential targeted therapy. |
| first_indexed | 2024-03-09T17:16:51Z |
| format | Article |
| id | doaj.art-0146402273114a5188addaef9aed13de |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T17:16:51Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0146402273114a5188addaef9aed13de2023-11-24T13:32:14ZengMDPI AGBiomolecules2218-273X2022-11-011212172310.3390/biom12121723Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and MetastasisZhuomin Tan0Wenyan Sun1Ya Li2Xingmeng Jiao3Mingliang Zhu4Junfei Zhang5Chen Qing6Yinnong Jia7Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaCollege of Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, ChinaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaColorectal cancer (CRC) is a common malignant tumor with a high frequency of recurrence and metastasis, which are the major causes of death in patients. The prerequisite for the invasion and metastasis is the strong mobility of CRC cells to transport far away from the original site to the distant organs and tissues, where they settle down and proliferate. It was reported that the epithelial-mesenchymal transition (EMT) is involved in the occurrence and development of various tumors in the entire process of tumor invasion and metastasis. Therefore, as a vital factor for the biological characteristics of tumor cells, EMT markers may serve as prognostic predictors and potential therapeutic targets in CRC. This article mainly reviews the current status of CRC with metastasis, the studies of EMT, the possible relationship of EMT with CRC, as well as the potential targeted therapy.https://www.mdpi.com/2218-273X/12/12/1723colorectal cancerEMTtumor invasion and metastasistargeted therapysignal pathway |
| spellingShingle | Zhuomin Tan Wenyan Sun Ya Li Xingmeng Jiao Mingliang Zhu Junfei Zhang Chen Qing Yinnong Jia Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis Biomolecules colorectal cancer EMT tumor invasion and metastasis targeted therapy signal pathway |
| title | Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis |
| title_full | Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis |
| title_fullStr | Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis |
| title_full_unstemmed | Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis |
| title_short | Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis |
| title_sort | current progress of emt a new direction of targeted therapy for colorectal cancer with invasion and metastasis |
| topic | colorectal cancer EMT tumor invasion and metastasis targeted therapy signal pathway |
| url | https://www.mdpi.com/2218-273X/12/12/1723 |
| work_keys_str_mv | AT zhuomintan currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT wenyansun currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT yali currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT xingmengjiao currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT mingliangzhu currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT junfeizhang currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT chenqing currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis AT yinnongjia currentprogressofemtanewdirectionoftargetedtherapyforcolorectalcancerwithinvasionandmetastasis |