Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis
<p>Mutation in the “nude” gene, i.e. the <i>FoxN1</i> gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional <i>FoxN1</i> gene knockout and transgenic...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2012-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v08p1156.htm |
| _version_ | 1811300768320323584 |
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| author | Zhijie Zhang, Preston Burnley, Brandon Coder, Dong-Ming Su |
| author_facet | Zhijie Zhang, Preston Burnley, Brandon Coder, Dong-Ming Su |
| author_sort | Zhijie Zhang, Preston Burnley, Brandon Coder, Dong-Ming Su |
| collection | DOAJ |
| description | <p>Mutation in the “nude” gene, i.e. the <i>FoxN1</i> gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional <i>FoxN1</i> gene knockout and transgenic mouse models have been generated for studies of <i>FoxN1</i> gene function related to skin and immune diseases, and for cancer models. It appeared that FoxN1's role was fully understood and the nude mouse model was fully utilized. However, in recent years, with the development of inducible gene knockout/knockin mouse models with the <i>loxP</i>-Cre(ER<sup>T</sup>) and diphtheria toxin receptor-induced cell abolished systems, it appears that the complete repertoire of FoxN1's roles and deep-going usage of nude mouse model in immune function studies have just begun. Here we summarize the research progress made by several recent works studying the role of <i>FoxN1</i> in the thymus and utilizing nude and “second (conditional) nude” mouse models for studies of T-cell development and function. We also raise questions and propose further consideration of <i>FoxN1</i> functions and utilizing this mouse model for immune function studies.</p> |
| first_indexed | 2024-04-13T06:56:32Z |
| format | Article |
| id | doaj.art-0146f0a4510c464889354ef4b9953a1a |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-13T06:56:32Z |
| publishDate | 2012-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-0146f0a4510c464889354ef4b9953a1a2022-12-22T02:57:14ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882012-01-018811561167Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-LymphopoiesisZhijie Zhang, Preston Burnley, Brandon Coder, Dong-Ming Su<p>Mutation in the “nude” gene, i.e. the <i>FoxN1</i> gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional <i>FoxN1</i> gene knockout and transgenic mouse models have been generated for studies of <i>FoxN1</i> gene function related to skin and immune diseases, and for cancer models. It appeared that FoxN1's role was fully understood and the nude mouse model was fully utilized. However, in recent years, with the development of inducible gene knockout/knockin mouse models with the <i>loxP</i>-Cre(ER<sup>T</sup>) and diphtheria toxin receptor-induced cell abolished systems, it appears that the complete repertoire of FoxN1's roles and deep-going usage of nude mouse model in immune function studies have just begun. Here we summarize the research progress made by several recent works studying the role of <i>FoxN1</i> in the thymus and utilizing nude and “second (conditional) nude” mouse models for studies of T-cell development and function. We also raise questions and propose further consideration of <i>FoxN1</i> functions and utilizing this mouse model for immune function studies.</p>http://www.biolsci.org/v08p1156.htm |
| spellingShingle | Zhijie Zhang, Preston Burnley, Brandon Coder, Dong-Ming Su Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis International Journal of Biological Sciences |
| title | Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis |
| title_full | Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis |
| title_fullStr | Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis |
| title_full_unstemmed | Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis |
| title_short | Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis |
| title_sort | insights on foxn1 biological significance and usages of the 8220 nude 8221 mouse in studies of t lymphopoiesis |
| url | http://www.biolsci.org/v08p1156.htm |
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