Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale

Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale

Abstract Background Cytoprotection afforded by mitochondrial ATP-sensitive K+-channel (mKATP-channel) opener diazoxide (DZ) largely depends on the activation of potassium cycle with eventual modulation of mitochondrial functions and ROS production. However, generally these effects were studied in th...

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Bibliographic Details
Main Authors: Olga Akopova, Liudmila Kolchinskaya, Valentina Nosar, Iryna Mankovska, Vadim Sagach
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Molecular and Cell Biology
Subjects:
Diazoxide
Potassium transport
mKATP-channel
Potassium cycle
Mild uncoupling
ROS production
Online Access:http://link.springer.com/article/10.1186/s12860-020-00275-0

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