Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods

In the current study, bioinformatics approach has been utilized to discover the sequences and structures analysis of IL-17A of breast cancer and compares with normal sequence from NCBI. The current study was aimed to discuss the possibility of using IL-17A as a marker for patients with breast cancer...

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Main Authors: Abdalrahman Mohammed‬, Abbas Al-Janabi
Format: Article
Language:English
Published: University of Technology, Baghdad 2022-06-01
Series:Journal of Applied Sciences and Nanotechnology
Subjects:
Online Access:https://jasn.uotechnology.edu.iq/article_17834_85cb267bfb40e11b1d952c8560f81965.pdf
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author Abdalrahman Mohammed‬
Abbas Al-Janabi
author_facet Abdalrahman Mohammed‬
Abbas Al-Janabi
author_sort Abdalrahman Mohammed‬
collection DOAJ
description In the current study, bioinformatics approach has been utilized to discover the sequences and structures analysis of IL-17A of breast cancer and compares with normal sequence from NCBI. The current study was aimed to discuss the possibility of using IL-17A as a marker for patients with breast cancer. Also, the effect of mutation on the physicochemical properties and structure of IL-17A. Sixty blood samples were examined from patients with breast cancer (aged between 20 and 75 years old). In patients with breast cancer, there were missense mutations and deletion mutations detected by BLAST. Furthermore, the current study determined the physicochemical properties of IL-17A, such as their hydrophilic nature; alpha–helical structure, and 3D structure. The results of this study show that IL-17A consider as a marker for the patient with breast cancer. Also, the mutations on IL-17A gene affected the structure and physicochemical properties of the Interleukin-17A protein complex.
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spelling doaj.art-014a2d870ed3485ea5a3cb45df88854b2022-12-22T00:23:58ZengUniversity of Technology, BaghdadJournal of Applied Sciences and Nanotechnology2788-68672022-06-0122798510.53293/jasn.2021.3878.105217834Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics MethodsAbdalrahman Mohammed‬0Abbas Al-Janabi1Biotechnology Division, Department of Applied Sciences, University of Technology – IraqBiotechnology Division, Department of Applied Sciences, University of Technology – IraqIn the current study, bioinformatics approach has been utilized to discover the sequences and structures analysis of IL-17A of breast cancer and compares with normal sequence from NCBI. The current study was aimed to discuss the possibility of using IL-17A as a marker for patients with breast cancer. Also, the effect of mutation on the physicochemical properties and structure of IL-17A. Sixty blood samples were examined from patients with breast cancer (aged between 20 and 75 years old). In patients with breast cancer, there were missense mutations and deletion mutations detected by BLAST. Furthermore, the current study determined the physicochemical properties of IL-17A, such as their hydrophilic nature; alpha–helical structure, and 3D structure. The results of this study show that IL-17A consider as a marker for the patient with breast cancer. Also, the mutations on IL-17A gene affected the structure and physicochemical properties of the Interleukin-17A protein complex.https://jasn.uotechnology.edu.iq/article_17834_85cb267bfb40e11b1d952c8560f81965.pdfil-17abioinformaticsbreast cancer
spellingShingle Abdalrahman Mohammed‬
Abbas Al-Janabi
Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods
Journal of Applied Sciences and Nanotechnology
il-17a
bioinformatics
breast cancer
title Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods
title_full Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods
title_fullStr Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods
title_full_unstemmed Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods
title_short Computational Analysis of Interleukin 17A Activity in Breast Cancer Patients Using Bioinformatics Methods
title_sort computational analysis of interleukin 17a activity in breast cancer patients using bioinformatics methods
topic il-17a
bioinformatics
breast cancer
url https://jasn.uotechnology.edu.iq/article_17834_85cb267bfb40e11b1d952c8560f81965.pdf
work_keys_str_mv AT abdalrahmanmohammed computationalanalysisofinterleukin17aactivityinbreastcancerpatientsusingbioinformaticsmethods
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