Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia
Background and objective: Patients on blood transfusion may develop complications related to iron overload and the effects of chelating agents (drugs), which adversely affect the liver in thalassemia, which is a genetic blood disorder of hemoglobin synthesis that causes severe anemia. This study aim...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hawler Medical University
2020-12-01
|
| Series: | Zanco Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/792 |
| _version_ | 1818879569587863552 |
|---|---|
| author | Rasul Jameel Ali Dler Rostum Ali Zhyan Ismail Ahmed Amal Aziz Ahmed Dilvin Saleh Hassen Rozy Mohammed Tahir |
| author_facet | Rasul Jameel Ali Dler Rostum Ali Zhyan Ismail Ahmed Amal Aziz Ahmed Dilvin Saleh Hassen Rozy Mohammed Tahir |
| author_sort | Rasul Jameel Ali |
| collection | DOAJ |
| description | Background and objective: Patients on blood transfusion may develop complications related to iron overload and the effects of chelating agents (drugs), which adversely affect the liver in thalassemia, which is a genetic blood disorder of hemoglobin synthesis that causes severe anemia. This study aimed to assess the effect of deferasirox and deferoxamine drugs on liver enzyme activities (aspartate transaminase, alanine transaminase, and alkaline phosphatase), and serum ferritin level in β_thalassemic patients.
Methods: This study was carried out in Erbil city from October 2017 to February 2018. Blood specimens were collected in Hawler thalassemia center and Raparin hospital. The samples included 105 individuals; 70 β-thalassemic patients (35 treated by deferasirox as group A and 35 treated by deferoxamine as group B), and 35 healthy individuals (control group C).
Results: The serum aspartate transaminase and alkaline phosphatase activities in β-thalassemic patients were higher than that of controls. The serum alanine transaminase activity in the patients' groups showed non-significant elevation than that of controls. The serum ferritin level in the patients was significantly higher than that of controls.
Conclusion: Our finding showed that both deferasirox and deferoxamine drugs affect liver enzymes and increase ferritin level. |
| first_indexed | 2024-12-19T14:32:10Z |
| format | Article |
| id | doaj.art-014c7269b3644490997d9a1d8268a588 |
| institution | Directory Open Access Journal |
| issn | 1995-5588 1995-5596 |
| language | English |
| last_indexed | 2024-12-19T14:32:10Z |
| publishDate | 2020-12-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj.art-014c7269b3644490997d9a1d8268a5882022-12-21T20:17:25ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962020-12-0124335435910.15218/zjms.2020.042Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemiaRasul Jameel Ali0Dler Rostum Ali1Zhyan Ismail Ahmed2Amal Aziz Ahmed3Dilvin Saleh Hassen4Rozy Mohammed Tahir5Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq.Department of Clinical Biochemistry, College of Medicine, Hawler Medical University, Erbil, Iraq.Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq.Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq.Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq.Department of Clinical Biochemistry, College of Health Sciences, Hawler Medical University, Erbil, Iraq.Background and objective: Patients on blood transfusion may develop complications related to iron overload and the effects of chelating agents (drugs), which adversely affect the liver in thalassemia, which is a genetic blood disorder of hemoglobin synthesis that causes severe anemia. This study aimed to assess the effect of deferasirox and deferoxamine drugs on liver enzyme activities (aspartate transaminase, alanine transaminase, and alkaline phosphatase), and serum ferritin level in β_thalassemic patients. Methods: This study was carried out in Erbil city from October 2017 to February 2018. Blood specimens were collected in Hawler thalassemia center and Raparin hospital. The samples included 105 individuals; 70 β-thalassemic patients (35 treated by deferasirox as group A and 35 treated by deferoxamine as group B), and 35 healthy individuals (control group C). Results: The serum aspartate transaminase and alkaline phosphatase activities in β-thalassemic patients were higher than that of controls. The serum alanine transaminase activity in the patients' groups showed non-significant elevation than that of controls. The serum ferritin level in the patients was significantly higher than that of controls. Conclusion: Our finding showed that both deferasirox and deferoxamine drugs affect liver enzymes and increase ferritin level.https://zjms.hmu.edu.krd/index.php/zjms/article/view/792β-thalassemiadeferasiroxdeferoxamineliver enzymes; ferritin |
| spellingShingle | Rasul Jameel Ali Dler Rostum Ali Zhyan Ismail Ahmed Amal Aziz Ahmed Dilvin Saleh Hassen Rozy Mohammed Tahir Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia Zanco Journal of Medical Sciences β-thalassemia deferasirox deferoxamine liver enzymes; ferritin |
| title | Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia |
| title_full | Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia |
| title_fullStr | Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia |
| title_full_unstemmed | Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia |
| title_short | Comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta-thalassemia |
| title_sort | comparison of deferasirox and deferoxamine effect on liver enzyme activities and ferritin level in patients with beta thalassemia |
| topic | β-thalassemia deferasirox deferoxamine liver enzymes; ferritin |
| url | https://zjms.hmu.edu.krd/index.php/zjms/article/view/792 |
| work_keys_str_mv | AT rasuljameelali comparisonofdeferasiroxanddeferoxamineeffectonliverenzymeactivitiesandferritinlevelinpatientswithbetathalassemia AT dlerrostumali comparisonofdeferasiroxanddeferoxamineeffectonliverenzymeactivitiesandferritinlevelinpatientswithbetathalassemia AT zhyanismailahmed comparisonofdeferasiroxanddeferoxamineeffectonliverenzymeactivitiesandferritinlevelinpatientswithbetathalassemia AT amalazizahmed comparisonofdeferasiroxanddeferoxamineeffectonliverenzymeactivitiesandferritinlevelinpatientswithbetathalassemia AT dilvinsalehhassen comparisonofdeferasiroxanddeferoxamineeffectonliverenzymeactivitiesandferritinlevelinpatientswithbetathalassemia AT rozymohammedtahir comparisonofdeferasiroxanddeferoxamineeffectonliverenzymeactivitiesandferritinlevelinpatientswithbetathalassemia |