HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis
Background: The linkage of HLA-DQB1*0301 to autoimmune disorders is becoming more common in literature. Despite bullous pemphigoid (BP) and pemphigus vulgaris (PV) both having similar symptoms, such as blistering skin conditions, research has shown different relationships with HLAs. Methods: In t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2023-09-01
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| Series: | International Journal of Medical Students |
| Subjects: | |
| Online Access: | https://ijms.pitt.edu/IJMS/article/view/1594 |
| _version_ | 1827769300614643712 |
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| author | Dylan Thibaut Ryan Witcher Breana Barnes Kersten T. Schroeder |
| author_facet | Dylan Thibaut Ryan Witcher Breana Barnes Kersten T. Schroeder |
| author_sort | Dylan Thibaut |
| collection | DOAJ |
| description |
Background: The linkage of HLA-DQB1*0301 to autoimmune disorders is becoming more common in literature. Despite bullous pemphigoid (BP) and pemphigus vulgaris (PV) both having similar symptoms, such as blistering skin conditions, research has shown different relationships with HLAs.
Methods: In this systematic review, HLA-DQB1*0301 and the odds of developing BP and PV were explored. Google Scholar and Pubmed were consulted, and articles were included if living subjects were used, odds ratio was available or could be ascertained from the study, and if it was not a meta-analysis of other researcher’s works. MetaXL software was used to generate data for analysis and a forest plot was generated for each. Nine studies conducted between 1996 and 2021 met study selection criteria for the BP HLA-DQB1*0301 meta-analysis (1,340 patients and 6,673 controls) and five studies (247 patients and 2,435 controls) for PV.
Results: HLA-DQB1*0301 increased the odds of developing BP (OR= 1.64, 95% CI [1.44, 1.87], I2= 0%) yet decreased odds of PV (OR= 0.60, 95% CI [0.40, 0.89], I2= 34%).
Conclusion: Results suggest HLA-DQB1*0301 may serve opposite roles in BP and PV despite similarity in symptoms, finding higher odds for developing BP versus lower odds for developing PV. Understanding this HLA’s function in each requires further exploration. Limitations of the analysis included minor asymmetry in the PV Doi plot, suggesting publication bias. No funding was used; study protocol was not registered.
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| first_indexed | 2024-03-11T12:23:20Z |
| format | Article |
| id | doaj.art-014dcf85aad14a4daa7a735ef9391023 |
| institution | Directory Open Access Journal |
| issn | 2076-6327 |
| language | English |
| last_indexed | 2024-03-11T12:23:20Z |
| publishDate | 2023-09-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj.art-014dcf85aad14a4daa7a735ef93910232023-11-06T15:10:25ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272023-09-0111310.5195/ijms.2023.1594HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-AnalysisDylan Thibaut0Ryan Witcher1Breana Barnes2Kersten T. Schroeder3Lake Erie College of Osteopathic Medicine- Bradenton; University of Central FloridaLake Erie College of Osteopathic Medicine- BradentonLake Erie College of Osteopathic Medicine- BradentonUniversity of Central Florida Background: The linkage of HLA-DQB1*0301 to autoimmune disorders is becoming more common in literature. Despite bullous pemphigoid (BP) and pemphigus vulgaris (PV) both having similar symptoms, such as blistering skin conditions, research has shown different relationships with HLAs. Methods: In this systematic review, HLA-DQB1*0301 and the odds of developing BP and PV were explored. Google Scholar and Pubmed were consulted, and articles were included if living subjects were used, odds ratio was available or could be ascertained from the study, and if it was not a meta-analysis of other researcher’s works. MetaXL software was used to generate data for analysis and a forest plot was generated for each. Nine studies conducted between 1996 and 2021 met study selection criteria for the BP HLA-DQB1*0301 meta-analysis (1,340 patients and 6,673 controls) and five studies (247 patients and 2,435 controls) for PV. Results: HLA-DQB1*0301 increased the odds of developing BP (OR= 1.64, 95% CI [1.44, 1.87], I2= 0%) yet decreased odds of PV (OR= 0.60, 95% CI [0.40, 0.89], I2= 34%). Conclusion: Results suggest HLA-DQB1*0301 may serve opposite roles in BP and PV despite similarity in symptoms, finding higher odds for developing BP versus lower odds for developing PV. Understanding this HLA’s function in each requires further exploration. Limitations of the analysis included minor asymmetry in the PV Doi plot, suggesting publication bias. No funding was used; study protocol was not registered. https://ijms.pitt.edu/IJMS/article/view/1594HLA-DQB1 antigenPemphigusPemphigoidBullousDQB1*0301Bullous pemphigoid |
| spellingShingle | Dylan Thibaut Ryan Witcher Breana Barnes Kersten T. Schroeder HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis International Journal of Medical Students HLA-DQB1 antigen Pemphigus Pemphigoid Bullous DQB1*0301 Bullous pemphigoid |
| title | HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis |
| title_full | HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis |
| title_fullStr | HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis |
| title_full_unstemmed | HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis |
| title_short | HLA-DQB1*0301 in Bullous Pemphigoid and Pemphigus Vulgaris: A Meta-Analysis |
| title_sort | hla dqb1 0301 in bullous pemphigoid and pemphigus vulgaris a meta analysis |
| topic | HLA-DQB1 antigen Pemphigus Pemphigoid Bullous DQB1*0301 Bullous pemphigoid |
| url | https://ijms.pitt.edu/IJMS/article/view/1594 |
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