Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study.
<h4>Purpose</h4>To analyze if tumor vessels can be visualized, segmented and quantified in glioblastoma patients with time of flight (ToF) angiography at 7 Tesla and multiscale vessel enhancement filtering.<h4>Materials and methods</h4>Twelve patients with newly diagnosed gli...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0110727 |
| _version_ | 1818729707781226496 |
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| author | Alexander Radbruch Oliver Eidel Benedikt Wiestler Daniel Paech Sina Burth Philipp Kickingereder Martha Nowosielski Philipp Bäumer Wolfgang Wick Heinz-Peter Schlemmer Martin Bendszus Mark Ladd Armin Michael Nagel Sabine Heiland |
| author_facet | Alexander Radbruch Oliver Eidel Benedikt Wiestler Daniel Paech Sina Burth Philipp Kickingereder Martha Nowosielski Philipp Bäumer Wolfgang Wick Heinz-Peter Schlemmer Martin Bendszus Mark Ladd Armin Michael Nagel Sabine Heiland |
| author_sort | Alexander Radbruch |
| collection | DOAJ |
| description | <h4>Purpose</h4>To analyze if tumor vessels can be visualized, segmented and quantified in glioblastoma patients with time of flight (ToF) angiography at 7 Tesla and multiscale vessel enhancement filtering.<h4>Materials and methods</h4>Twelve patients with newly diagnosed glioblastoma were examined with ToF angiography (TR = 15 ms, TE = 4.8 ms, flip angle = 15°, FOV = 160 × 210 mm(2), voxel size: 0.31 × 0.31 × 0.40 mm(3)) on a whole-body 7 T MR system. A volume of interest (VOI) was placed within the border of the contrast enhancing part on T1-weighted images of the glioblastoma and a reference VOI was placed in the non-affected contralateral white matter. Automated segmentation and quantification of vessels within the two VOIs was achieved using multiscale vessel enhancement filtering in ImageJ.<h4>Results</h4>Tumor vessels were clearly visible in all patients. When comparing tumor and the reference VOI, total vessel surface (45.3 ± 13.9 mm(2) vs. 29.0 ± 21.0 mm(2) (p<0.035)) and number of branches (3.5 ± 1.8 vs. 1.0 ± 0.6 (p<0.001) per cubic centimeter were significantly higher, while mean vessel branch length was significantly lower (3.8 ± 1.5 mm vs 7.2 ± 2.8 mm (p<0.001)) in the tumor.<h4>Discussion</h4>ToF angiography at 7-Tesla MRI enables characterization and quantification of the internal vascular morphology of glioblastoma and may be used for the evaluation of therapy response within future studies. |
| first_indexed | 2024-12-17T22:50:10Z |
| format | Article |
| id | doaj.art-0151248bc23947d4918a421cca33f68f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T22:50:10Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0151248bc23947d4918a421cca33f68f2022-12-21T21:29:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11072710.1371/journal.pone.0110727Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study.Alexander RadbruchOliver EidelBenedikt WiestlerDaniel PaechSina BurthPhilipp KickingerederMartha NowosielskiPhilipp BäumerWolfgang WickHeinz-Peter SchlemmerMartin BendszusMark LaddArmin Michael NagelSabine Heiland<h4>Purpose</h4>To analyze if tumor vessels can be visualized, segmented and quantified in glioblastoma patients with time of flight (ToF) angiography at 7 Tesla and multiscale vessel enhancement filtering.<h4>Materials and methods</h4>Twelve patients with newly diagnosed glioblastoma were examined with ToF angiography (TR = 15 ms, TE = 4.8 ms, flip angle = 15°, FOV = 160 × 210 mm(2), voxel size: 0.31 × 0.31 × 0.40 mm(3)) on a whole-body 7 T MR system. A volume of interest (VOI) was placed within the border of the contrast enhancing part on T1-weighted images of the glioblastoma and a reference VOI was placed in the non-affected contralateral white matter. Automated segmentation and quantification of vessels within the two VOIs was achieved using multiscale vessel enhancement filtering in ImageJ.<h4>Results</h4>Tumor vessels were clearly visible in all patients. When comparing tumor and the reference VOI, total vessel surface (45.3 ± 13.9 mm(2) vs. 29.0 ± 21.0 mm(2) (p<0.035)) and number of branches (3.5 ± 1.8 vs. 1.0 ± 0.6 (p<0.001) per cubic centimeter were significantly higher, while mean vessel branch length was significantly lower (3.8 ± 1.5 mm vs 7.2 ± 2.8 mm (p<0.001)) in the tumor.<h4>Discussion</h4>ToF angiography at 7-Tesla MRI enables characterization and quantification of the internal vascular morphology of glioblastoma and may be used for the evaluation of therapy response within future studies.https://doi.org/10.1371/journal.pone.0110727 |
| spellingShingle | Alexander Radbruch Oliver Eidel Benedikt Wiestler Daniel Paech Sina Burth Philipp Kickingereder Martha Nowosielski Philipp Bäumer Wolfgang Wick Heinz-Peter Schlemmer Martin Bendszus Mark Ladd Armin Michael Nagel Sabine Heiland Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study. PLoS ONE |
| title | Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study. |
| title_full | Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study. |
| title_fullStr | Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study. |
| title_full_unstemmed | Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study. |
| title_short | Quantification of tumor vessels in glioblastoma patients using time-of-flight angiography at 7 Tesla: a feasibility study. |
| title_sort | quantification of tumor vessels in glioblastoma patients using time of flight angiography at 7 tesla a feasibility study |
| url | https://doi.org/10.1371/journal.pone.0110727 |
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