Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production

Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production

Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation. However, no effective therapy is available now. Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown to protect the heart from aldehyde toxicity such as 4-hydroxy-2-...

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Bibliographic Details
Main Authors: Rui Zhang, Baoshan Liu, Xinhui Fan, Wenjun Wang, Tonghui Xu, Shujian Wei, Wen Zheng, Qiuhuan Yuan, Luyao Gao, Xinxin Yin, Boyuan Zheng, Chuanxin Zhang, Shuai Zhang, Kehui Yang, Mengyang Xue, Shuo Wang, Feng Xu, Jiali Wang, Yihai Cao, Yuguo Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
aldehyde dehydrogenase 2
cardiopulmonary resuscitation
post-cardiac arrest myocardial dysfunction
cardiomyocyte death
mitochondrial reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00373/full

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