Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes

Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes

Sphingosine 1-phosphate (S1P) has been implicated in brown adipose tissue (BAT) formation and energy consumption; however, the mechanistic role of sphingolipids, including S1P, in BAT remains unclear. Here, we showed that, in mice, BAT activation by cold exposure upregulated mRNA and protein express...

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Bibliographic Details
Main Authors: Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Lipid Research
Subjects:
Adipose tissue
brown
lipid droplets
lipase
lipolysis
lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001232

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