Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study
ObjectiveThe effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).MethodsForty independent sing...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1290731/full |
| _version_ | 1797302846934220800 |
|---|---|
| author | Yunfeng Yu Xinyu Yang Gang Hu Keke Tong Yuman Yin Rong Yu |
| author_facet | Yunfeng Yu Xinyu Yang Gang Hu Keke Tong Yuman Yin Rong Yu |
| author_sort | Yunfeng Yu |
| collection | DOAJ |
| description | ObjectiveThe effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).MethodsForty independent single nucleotide polymorphisms (SNPs) associated with tea intake were selected from UK Biobank. SNPs for uric acid were obtained from BioBank Japan, SNPs for gout were obtained from UK Biobank, and SNPs for gout due to impairment of renal function and idiopathic gout were derived from FinnGen. The causal relationship of exposure-outcome was tested using inverse variance weighted, MR-Egger and weighted median. MR-Egger intercept was employed to assess horizontal pleiotropy, Cochran’s Q test was used to assess heterogeneity, and leave-one-out sensitivity analysis was utilized to analyze the stability of the results.ResultsThe results of MR analysis showed that tea intake was negatively associated with gout due to impairment of renal function (OR 0.997, 95% CI 0.994 to 0.999, P = 0.017), whereas there was no causal association with gout, idiopathic gout, and uric acid (P > 0.05), for which sensitivity analysis suggested that these results were robust.ConclusionsThere was a genetic predisposition effect of increased tea intake on the reduced risk of gout due to impairment of renal function, whereas there was no such effect on gout, idiopathic gout, and uric acid. Tea intake may become an important option in the dietary treatment of gout due to impairment of renal function. |
| first_indexed | 2024-03-07T23:44:49Z |
| format | Article |
| id | doaj.art-0152c814fa5a4b9b93bb5451feb33a7f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T23:44:49Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0152c814fa5a4b9b93bb5451feb33a7f2024-02-19T14:42:48ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011410.3389/fendo.2023.12907311290731Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization studyYunfeng Yu0Xinyu Yang1Gang Hu2Keke Tong3Yuman Yin4Rong Yu5Department of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaCollege of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaCollege of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Gastroenterology, The Hospital of Hunan University of Traditional Chinese Medicine, Changde, Hunan, ChinaCollege of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaObjectiveThe effect of tea on gout and uric acid is still controversial. This study aims to analyze the effect of tea intake on genetic predisposition to gout, idiopathic gout, gout due to impairment of renal function as well as uric acid by Mendelian randomization (MR).MethodsForty independent single nucleotide polymorphisms (SNPs) associated with tea intake were selected from UK Biobank. SNPs for uric acid were obtained from BioBank Japan, SNPs for gout were obtained from UK Biobank, and SNPs for gout due to impairment of renal function and idiopathic gout were derived from FinnGen. The causal relationship of exposure-outcome was tested using inverse variance weighted, MR-Egger and weighted median. MR-Egger intercept was employed to assess horizontal pleiotropy, Cochran’s Q test was used to assess heterogeneity, and leave-one-out sensitivity analysis was utilized to analyze the stability of the results.ResultsThe results of MR analysis showed that tea intake was negatively associated with gout due to impairment of renal function (OR 0.997, 95% CI 0.994 to 0.999, P = 0.017), whereas there was no causal association with gout, idiopathic gout, and uric acid (P > 0.05), for which sensitivity analysis suggested that these results were robust.ConclusionsThere was a genetic predisposition effect of increased tea intake on the reduced risk of gout due to impairment of renal function, whereas there was no such effect on gout, idiopathic gout, and uric acid. Tea intake may become an important option in the dietary treatment of gout due to impairment of renal function.https://www.frontiersin.org/articles/10.3389/fendo.2023.1290731/fulltea intakecaffeinegoutgout due to impairment of renal functionuric acidMendelian randomization |
| spellingShingle | Yunfeng Yu Xinyu Yang Gang Hu Keke Tong Yuman Yin Rong Yu Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study Frontiers in Endocrinology tea intake caffeine gout gout due to impairment of renal function uric acid Mendelian randomization |
| title | Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study |
| title_full | Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study |
| title_fullStr | Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study |
| title_full_unstemmed | Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study |
| title_short | Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study |
| title_sort | effect of tea intake on genetic predisposition to gout and uric acid a mendelian randomization study |
| topic | tea intake caffeine gout gout due to impairment of renal function uric acid Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1290731/full |
| work_keys_str_mv | AT yunfengyu effectofteaintakeongeneticpredispositiontogoutanduricacidamendelianrandomizationstudy AT xinyuyang effectofteaintakeongeneticpredispositiontogoutanduricacidamendelianrandomizationstudy AT ganghu effectofteaintakeongeneticpredispositiontogoutanduricacidamendelianrandomizationstudy AT keketong effectofteaintakeongeneticpredispositiontogoutanduricacidamendelianrandomizationstudy AT yumanyin effectofteaintakeongeneticpredispositiontogoutanduricacidamendelianrandomizationstudy AT rongyu effectofteaintakeongeneticpredispositiontogoutanduricacidamendelianrandomizationstudy |