The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria
Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare marke...
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MDPI AG
2022-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/8/1590 |
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| author | Sabina Galiniak Mateusz Mołoń Marek Biesiadecki Agnieszka Bożek Marta Rachel |
| author_facet | Sabina Galiniak Mateusz Mołoń Marek Biesiadecki Agnieszka Bożek Marta Rachel |
| author_sort | Sabina Galiniak |
| collection | DOAJ |
| description | Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases. |
| first_indexed | 2024-03-09T04:45:32Z |
| format | Article |
| id | doaj.art-01574cb918ec4cf7a9ee05dced4192bd |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T04:45:32Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-01574cb918ec4cf7a9ee05dced4192bd2023-12-03T13:16:08ZengMDPI AGAntioxidants2076-39212022-08-01118159010.3390/antiox11081590The Role of Oxidative Stress in Atopic Dermatitis and Chronic UrticariaSabina Galiniak0Mateusz Mołoń1Marek Biesiadecki2Agnieszka Bożek3Marta Rachel4Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, PolandDepartment of Biology, Institute of Biology and Biotechnology, Rzeszow University, Zelwerowicza 4, 35-601 Rzeszow, PolandInstitute of Medical Sciences, Medical College of Rzeszow University, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, PolandDepartment of Allergology and Cystic Fibrosis, Provincial Hospital No. 2 in Rzeszow, Lwowska 60, 35-301 Rzeszow, PolandInstitute of Medical Sciences, Medical College of Rzeszow University, Rzeszow University, Warzywna 1a, 35-310 Rzeszow, PolandAtopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.https://www.mdpi.com/2076-3921/11/8/1590atopic dermatitischronic urticarialipid peroxidationprotein oxidation |
| spellingShingle | Sabina Galiniak Mateusz Mołoń Marek Biesiadecki Agnieszka Bożek Marta Rachel The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria Antioxidants atopic dermatitis chronic urticaria lipid peroxidation protein oxidation |
| title | The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria |
| title_full | The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria |
| title_fullStr | The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria |
| title_full_unstemmed | The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria |
| title_short | The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria |
| title_sort | role of oxidative stress in atopic dermatitis and chronic urticaria |
| topic | atopic dermatitis chronic urticaria lipid peroxidation protein oxidation |
| url | https://www.mdpi.com/2076-3921/11/8/1590 |
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