Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results
Introduction:Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies.Methods:This study retrospectively evalua...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-11-01
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| Series: | İstanbul Medical Journal |
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http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/mucormycosis-in-hematologic-malignancies-clinical-/49705
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| _version_ | 1797914784352436224 |
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| author | Nagehan Didem Sarı Istemi Serin Tolga Kırgezen Mehmet Hilmi Doğu |
| author_facet | Nagehan Didem Sarı Istemi Serin Tolga Kırgezen Mehmet Hilmi Doğu |
| author_sort | Nagehan Didem Sarı |
| collection | DOAJ |
| description | Introduction:Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies.Methods:This study retrospectively evaluated patients with mucormycosis diagnosis between January 2015 and December 2019, including demographic features, hematologic diseases and comorbidities, radiological evaluations, symptoms and signs, treatments, and outcomes.Results:Maxillofacial 9/19 (47.37%) of patients and 10/19 (59.9%) rhinoorbital mucor. Hematologic malignancy was observed in 15 (78.95%) patients, whereas others had additional pre-disposing factors, such as diabetes mellitus and chronic renal failure. The most common find-ings were persistent fever, mucopurulent nasal flux, and periorbital edema. Endoscopic sinus surgery + medication was administered in 12/19 (62.2%) patients and antifungal therapy in 7/19 (37.8%). In addition, 15/19 (79.95%) patients died and 4/19 recovered with sequela.Conclusion:The first large-scale mucormycosis study from our country will guide in determining the treatment algorithm. Effective and early surgery and antifungal application reduce mortality in mucormycosis by early diagnosis and multidisciplinary approach, without bone destruction in the paranasal sinus computed tomography with recurrent fever and earlystage sinusitis finding by performing a biopsy. |
| first_indexed | 2024-04-10T12:31:33Z |
| format | Article |
| id | doaj.art-0158689f9e3f41e4b56c2b3eabf5c4b3 |
| institution | Directory Open Access Journal |
| issn | 2619-9793 2148-094X |
| language | English |
| last_indexed | 2024-04-10T12:31:33Z |
| publishDate | 2021-11-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj.art-0158689f9e3f41e4b56c2b3eabf5c4b32023-02-15T16:14:52ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2021-11-0122424524910.4274/imj.galenos.2021.6587213049054Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment ResultsNagehan Didem Sarı0Istemi Serin1Tolga Kırgezen2Mehmet Hilmi Doğu3 University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Hematology, İstanbul, Turkey University of Health Sciences Turkey, İstanbul Training and Research Hospital, Clinic of Otorlaryngology, İstanbul, Turkey Istinye University, Liv Hospital Ulus, Department of Internal Medicine, İstanbul, Turkey Introduction:Mucormycosis is an aggressive-progressive invasive fungal infection caused by mold fungi in the division of mucorales of the zygomycetes class with high mortality, and is the most common fungal infection in patients with hematologic malignancies.Methods:This study retrospectively evaluated patients with mucormycosis diagnosis between January 2015 and December 2019, including demographic features, hematologic diseases and comorbidities, radiological evaluations, symptoms and signs, treatments, and outcomes.Results:Maxillofacial 9/19 (47.37%) of patients and 10/19 (59.9%) rhinoorbital mucor. Hematologic malignancy was observed in 15 (78.95%) patients, whereas others had additional pre-disposing factors, such as diabetes mellitus and chronic renal failure. The most common find-ings were persistent fever, mucopurulent nasal flux, and periorbital edema. Endoscopic sinus surgery + medication was administered in 12/19 (62.2%) patients and antifungal therapy in 7/19 (37.8%). In addition, 15/19 (79.95%) patients died and 4/19 recovered with sequela.Conclusion:The first large-scale mucormycosis study from our country will guide in determining the treatment algorithm. Effective and early surgery and antifungal application reduce mortality in mucormycosis by early diagnosis and multidisciplinary approach, without bone destruction in the paranasal sinus computed tomography with recurrent fever and earlystage sinusitis finding by performing a biopsy. http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/mucormycosis-in-hematologic-malignancies-clinical-/49705 fungal infectionmucormycosishematology |
| spellingShingle | Nagehan Didem Sarı Istemi Serin Tolga Kırgezen Mehmet Hilmi Doğu Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results İstanbul Medical Journal fungal infection mucormycosis hematology |
| title | Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results |
| title_full | Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results |
| title_fullStr | Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results |
| title_full_unstemmed | Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results |
| title_short | Mucormycosis in Hematologic Malignancies: Clinical Follow-Up and Treatment Results |
| title_sort | mucormycosis in hematologic malignancies clinical follow up and treatment results |
| topic | fungal infection mucormycosis hematology |
| url |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/mucormycosis-in-hematologic-malignancies-clinical-/49705
|
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