The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i>
Probiotic supplements have been used to decrease the gut carriage of antimicrobial-resistant <i>Enterobacterales</i> through changes in the microbiota and metabolomes, nutrition competition, and the secretion of antimicrobial proteins. Many probiotics have shown <i>Enterobacterales...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/9/1086 |
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| author | Yuan-Pin Hung Ching-Chi Lee Jen-Chieh Lee Pei-Jane Tsai Po-Ren Hsueh Wen-Chien Ko |
| author_facet | Yuan-Pin Hung Ching-Chi Lee Jen-Chieh Lee Pei-Jane Tsai Po-Ren Hsueh Wen-Chien Ko |
| author_sort | Yuan-Pin Hung |
| collection | DOAJ |
| description | Probiotic supplements have been used to decrease the gut carriage of antimicrobial-resistant <i>Enterobacterales</i> through changes in the microbiota and metabolomes, nutrition competition, and the secretion of antimicrobial proteins. Many probiotics have shown <i>Enterobacterales</i>-inhibiting effects ex vivo and in vivo. In livestock, probiotics have been widely used to eradicate colon or environmental antimicrobial-resistant <i>Enterobacterales</i> colonization with promising efficacy for many years by oral supplementation, in ovo use, or as environmental disinfectants. In humans, probiotics have been used as oral supplements for infants to decease potential gut pathogenic <i>Enterobacterales</i>, and probiotic mixtures, especially, have exhibited positive results. In contrast to the beneficial effects in infants, for adults, probiotic supplements might decrease potentially pathogenic <i>Enterobacterales</i>, but they fail to completely eradicate them in the gut. However, there are several ways to improve the effects of probiotics, including the discovery of probiotics with gut-protection ability and antimicrobial effects, the modification of delivery methods, and the discovery of engineered probiotics. The search for multifunctional probiotics and synbiotics could render the eradication of “bad” <i>Enterobacterales</i> in the human gut via probiotic administration achievable in the future. |
| first_indexed | 2024-03-10T07:56:41Z |
| format | Article |
| id | doaj.art-015b140185974535ac29d39057b59bb5 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T07:56:41Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-015b140185974535ac29d39057b59bb52023-11-22T11:46:03ZengMDPI AGAntibiotics2079-63822021-09-01109108610.3390/antibiotics10091086The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i>Yuan-Pin Hung0Ching-Chi Lee1Jen-Chieh Lee2Pei-Jane Tsai3Po-Ren Hsueh4Wen-Chien Ko5Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, TaiwanDepartment of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 704, TaiwanDepartment of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 704, TaiwanDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 705, TaiwanDepartments of Laboratory Medicine and Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung 404, TaiwanDepartment of Internal Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 704, TaiwanProbiotic supplements have been used to decrease the gut carriage of antimicrobial-resistant <i>Enterobacterales</i> through changes in the microbiota and metabolomes, nutrition competition, and the secretion of antimicrobial proteins. Many probiotics have shown <i>Enterobacterales</i>-inhibiting effects ex vivo and in vivo. In livestock, probiotics have been widely used to eradicate colon or environmental antimicrobial-resistant <i>Enterobacterales</i> colonization with promising efficacy for many years by oral supplementation, in ovo use, or as environmental disinfectants. In humans, probiotics have been used as oral supplements for infants to decease potential gut pathogenic <i>Enterobacterales</i>, and probiotic mixtures, especially, have exhibited positive results. In contrast to the beneficial effects in infants, for adults, probiotic supplements might decrease potentially pathogenic <i>Enterobacterales</i>, but they fail to completely eradicate them in the gut. However, there are several ways to improve the effects of probiotics, including the discovery of probiotics with gut-protection ability and antimicrobial effects, the modification of delivery methods, and the discovery of engineered probiotics. The search for multifunctional probiotics and synbiotics could render the eradication of “bad” <i>Enterobacterales</i> in the human gut via probiotic administration achievable in the future.https://www.mdpi.com/2079-6382/10/9/1086probioticssynbioticsantimicrobial-resistant<i>Enterobacterales</i>gastrointestinal tractlivestock |
| spellingShingle | Yuan-Pin Hung Ching-Chi Lee Jen-Chieh Lee Pei-Jane Tsai Po-Ren Hsueh Wen-Chien Ko The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i> Antibiotics probiotics synbiotics antimicrobial-resistant <i>Enterobacterales</i> gastrointestinal tract livestock |
| title | The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i> |
| title_full | The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i> |
| title_fullStr | The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i> |
| title_full_unstemmed | The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i> |
| title_short | The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant <i>Enterobacterales</i> |
| title_sort | potential of probiotics to eradicate gut carriage of pathogenic or antimicrobial resistant i enterobacterales i |
| topic | probiotics synbiotics antimicrobial-resistant <i>Enterobacterales</i> gastrointestinal tract livestock |
| url | https://www.mdpi.com/2079-6382/10/9/1086 |
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