The genetic basis of aneuploidy tolerance in wild yeast

The genetic basis of aneuploidy tolerance in wild yeast

Aneuploidy is highly detrimental during development yet common in cancers and pathogenic fungi – what gives rise to differences in aneuploidy tolerance remains unclear. We previously showed that wild isolates of Saccharomyces cerevisiae tolerate chromosome amplification while laboratory strains used...

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Bibliographic Details
Main Authors: James Hose, Leah E Escalante, Katie J Clowers, H Auguste Dutcher, DeElegant Robinson, Venera Bouriakov, Joshua J Coon, Evgenia Shishkova, Audrey P Gasch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
aneuploidy
natural variation
proteotoxicity
wild strains
Online Access:https://elifesciences.org/articles/52063

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