Synthesis of Some Thienopyrimidine Derivatives

Synthesis of Some Thienopyrimidine Derivatives

Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo- pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2-amino-3-cyano-4,5-disubstituted thiophenes via rea...

Full description

Bibliographic Details
Main Authors:	Hassan M. Al-Hazimi, Hanan A. S. Al-Blowy, Fatma E. M. El-Baih
Format:	Article
Language:	English
Published:	MDPI AG 2006-07-01
Series:	Molecules
Subjects:	Thioxothienopyrimidinones alkyl- and arylalkylthiothienopyrimidinones thienopyrimidinones thienopyrimidines thienopyrimidinediones thienotriazolo- pyrimidinones.
Online Access:	http://www.mdpi.com/1420-3049/11/7/498/

Similar Items

In Silico Screening and Anticancer-Apoptotic Evaluation of Newly Synthesized Thienopyrimidine/Sulfonamide Hybrids
by: Elshaymaa I. Elmongy, et al.
Published: (2023-06-01)

Thienopyrimidine: A Promising Scaffold to Access Anti-Infective Agents
by: Prisca Lagardère, et al.
Published: (2021-12-01)

Design, Synthesis, and Biological Evaluation of Novel Thienopyrimidine Derivatives as PI3Kα Inhibitors
by: Lide Yu, et al.
Published: (2019-09-01)

Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
by: Reham R. Khattab, et al.
Published: (2021-01-01)

Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure
by: Elshaymaa I. Elmongy, et al.
Published: (2024-01-01)

In-Silico Screening of Novel Synthesized Thienopyrimidines Targeting Fms Related Receptor Tyrosine Kinase-3 and Their In-Vitro Biological Evaluation
by: Elshaymaa I. Elmongy, et al.
Published: (2022-01-01)

Synthesis and Cytotoxicity Assay of Aniline Substituted Thienopyrimidines for Anti-Colorectal Cancer Activity
by: Mahalakshmi Suresha Biradar, et al.
Published: (2023-01-01)

Synthesis, molecular modelling and biological evaluation of new 4-aminothiophene and thienopyrimidine compounds
by: Aisha Hossan, et al.
Published: (2023-12-01)

Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors
by: Joseph S. Saleh, et al.
Published: (2023-09-01)

Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells
by: Haneen Amawi, et al.
Published: (2019-05-01)

Design, Synthesis and Anticancer Activity of New Polycyclic: Imidazole, Thiazine, Oxathiine, Pyrrolo-Quinoxaline and Thienotriazolopyrimidine Derivatives
by: Ameen Ali Abu-Hashem, et al.
Published: (2021-04-01)

Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives
by: Saleh A. Bahashwan, et al.
Published: (2013-12-01)

In Silico Evaluation of a Promising Key Intermediate Thieno [2,3-d] Pyrimidine Derivative with Expected JAK2 Kinase Inhibitory Activity
by: Elshaymaa I. Elmongy, et al.
Published: (2022-03-01)

A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells
by: Diwakar Bastihalli Tukaramrao, et al.
Published: (2021-04-01)

In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers
by: Rana M. Abdelnaby, et al.
Published: (2022-06-01)

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[<i>b</i>]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation
by: Emad M. Gad, et al.
Published: (2020-05-01)

4-Substituted Thieno[3,2-<i>d</i>]pyrimidines as Dual-Stage Antiplasmodial Derivatives
by: Prisca Lagardère, et al.
Published: (2022-07-01)

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
by: Graziella Tocco, et al.
Published: (2023-09-01)

A Simple Synthesis of Some New Thienopyridine and Thienopyrimidine Derivatives
by: Ahmed M. M. El-Saghier
Published: (2002-10-01)

Design, synthesis, biological evaluation, and bio-computational modeling of imidazo, thieno, pyrimidopyrimidine, pyrimidodiazepene, and motifs as antimicrobial agents
by: El-Ahwany Maged F., et al.
Published: (2023-08-01)

New Pyrimidinone-Fused 1,4-Naphthoquinone Derivatives Inhibit the Growth of Drug Resistant Oral Bacteria
by: Kyungmin Kim, et al.
Published: (2020-06-01)

Comparative Computational Studies of 3,4-Dihydro-2,6-diaryl-4-oxo-pyrimidine-5-carbonitrile Derivatives as Potential Antinociceptive Agents
by: Francisco J. B. Mendonça Junior, et al.
Published: (2012-01-01)

Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds
by: Kamilla Rodrigues Rogerio, et al.
Published: (2018-06-01)

Chemical Modification of Curcumin into Its Semi-Synthetic Analogs Bearing Pyrimidinone Moiety as Anticancer Agents
by: Obaid Afzal, et al.
Published: (2022-10-01)

Copper-Catalyzed C–H Arylation of Fused-Pyrimidinone Derivatives Using Diaryliodonium Salts
by: Alexandra Pacheco-Benichou, et al.
Published: (2020-12-01)

Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines
by: Anelia Mavrova, et al.
Published: (2022-05-01)

Butadienyl Ketene: An Unexplored Intermediate in Organic Synthesis
by: Maninderjeet K. Mann, et al.
Published: (2024-04-01)

Iron Oxide Nanoparticles with Supramolecular Ureido-Pyrimidinone Coating for Antimicrobial Peptide Delivery
by: Chiara Turrina, et al.
Published: (2023-09-01)

Supramolecular Polycaprolactone-Based Polyurethanes with Thermally Activated Shape-Memory Behavior
by: Fabio Muscas, et al.
Published: (2022-08-01)

Industrial and laboratory alkylations/
by: Goldsby, Arthur R., et al.
Published: (1977)

1-Hydroxyalkylphosphonium Salts—Synthesis and Properties
by: Jakub Adamek, et al.
Published: (2023-12-01)

Synthesis of 3-(Pyridin-2-yl)quinazolin-2,4(1<i>H,</i>3<i>H</i>)-diones via Annulation of Anthranilic Esters with <i>N</i>-pyridyl Ureas
by: Svetlana O. Baykova, et al.
Published: (2023-04-01)

Palladium-catalyzed para-selective alkylation of electron-deficient arenes
by: Jiao, Zhiwei, et al.
Published: (2019)

Two Highly Effective Phase-Transfer Catalysts for the Enantioselective Synthesis of ?-Amino Acid Derivatives
by: Barry Lygo, et al.
Published: (2007-05-01)

Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action
by: Zukela Ruzi, et al.
Published: (2022-12-01)

<i>N</i>-4 Alkyl Cytosine Derivatives Synthesis: A New Approach
by: Mauro De Nisco, et al.
Published: (2022-02-01)

Supported heteropolyacid (HPW) catalysts for the continuaus alkylation of isobutane with 2 butene : the benefit of using MCM-41 with larger pore diameters /
by: Blasco, T.

Selective alkylation of toluene with methanol to produce para-Xylene /
by: Kaeding, W. W. (Warren William)

Mesoporous aluminosilicate MCM-41 as a convenient acid catalyst for Friedel-Crafts alkylation of a bulky aromatic compound with cinnamyl alcohol /
by: Armengol, Elvira

Q-Tube®-Assisted Alkylation and Arylation of Xanthines and Other N-H-Containing Heterocycles in Water
by: Cecilia Scimmi, et al.
Published: (2021-10-01)