A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy
Abstract Background Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone–proguanil (AP) is not recommended because of insufficient safety evidence. An anonymous, internet-based survey was disseminated to describe outcomes of pregnancies accidentally exposed to AP. Outcomes of in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Malaria Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12936-018-2352-z |
| _version_ | 1818338546521473024 |
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| author | Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman |
| author_facet | Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman |
| author_sort | Kathrine R. Tan |
| collection | DOAJ |
| description | Abstract Background Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone–proguanil (AP) is not recommended because of insufficient safety evidence. An anonymous, internet-based survey was disseminated to describe outcomes of pregnancies accidentally exposed to AP. Outcomes of interest included miscarriage (defined as pregnancy loss before 20 weeks), stillbirth (defined as pregnancy loss at or after 20 weeks), preterm birth or live birth prior to 37 weeks, and the presence of congenital anomalies. Results A total of 487 women responded and reported on 822 pregnancies. Of the 807 pregnancies with information available on exposure and outcomes, 10 (1.2%) had atovaquone–proguanil exposure, all in the first trimester, and all resulted in term births with no birth defects. Conclusions Use of an anti-malarial not recommended in pregnancy is likely to occur before the woman knows of her pregnancy. This study adds to the limited evidence of the safety of AP in pregnancy. Further study on use of AP in pregnancy should be a high priority, as an alternative option for the prevention of malaria in pregnancy in non-immune travellers is urgently needed. |
| first_indexed | 2024-12-13T15:12:50Z |
| format | Article |
| id | doaj.art-015c150366bb4a128418116f3f2f1b63 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-13T15:12:50Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-015c150366bb4a128418116f3f2f1b632022-12-21T23:40:48ZengBMCMalaria Journal1475-28752018-05-011711410.1186/s12936-018-2352-zA survey on outcomes of accidental atovaquone–proguanil exposure in pregnancyKathrine R. Tan0Jessica K. Fairley1Mengxi Wang2Julie R. Gutman3Malaria Branch, Center for Global Health, Centers for Disease Control and PreventionDepartment of Medicine, Division of Infectious Diseases, Emory University School of MedicineDepartment of Epidemiology, Rollins School of Public Health, Emory UniversityMalaria Branch, Center for Global Health, Centers for Disease Control and PreventionAbstract Background Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone–proguanil (AP) is not recommended because of insufficient safety evidence. An anonymous, internet-based survey was disseminated to describe outcomes of pregnancies accidentally exposed to AP. Outcomes of interest included miscarriage (defined as pregnancy loss before 20 weeks), stillbirth (defined as pregnancy loss at or after 20 weeks), preterm birth or live birth prior to 37 weeks, and the presence of congenital anomalies. Results A total of 487 women responded and reported on 822 pregnancies. Of the 807 pregnancies with information available on exposure and outcomes, 10 (1.2%) had atovaquone–proguanil exposure, all in the first trimester, and all resulted in term births with no birth defects. Conclusions Use of an anti-malarial not recommended in pregnancy is likely to occur before the woman knows of her pregnancy. This study adds to the limited evidence of the safety of AP in pregnancy. Further study on use of AP in pregnancy should be a high priority, as an alternative option for the prevention of malaria in pregnancy in non-immune travellers is urgently needed.http://link.springer.com/article/10.1186/s12936-018-2352-zMalariaPregnancyProphylaxisAtovaquone–proguanil |
| spellingShingle | Kathrine R. Tan Jessica K. Fairley Mengxi Wang Julie R. Gutman A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy Malaria Journal Malaria Pregnancy Prophylaxis Atovaquone–proguanil |
| title | A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
| title_full | A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
| title_fullStr | A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
| title_full_unstemmed | A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
| title_short | A survey on outcomes of accidental atovaquone–proguanil exposure in pregnancy |
| title_sort | survey on outcomes of accidental atovaquone proguanil exposure in pregnancy |
| topic | Malaria Pregnancy Prophylaxis Atovaquone–proguanil |
| url | http://link.springer.com/article/10.1186/s12936-018-2352-z |
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