VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, with an increasing incidence worldwide. The treatment of PTC is currently the subject of clinical controversy, making it critically important to identify molecular markers that would help improve the risk stratification...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-01-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/7850 |
| _version_ | 1797261342228348928 |
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| author | Lidija Todorović Boban Stanojević |
| author_facet | Lidija Todorović Boban Stanojević |
| author_sort | Lidija Todorović |
| collection | DOAJ |
| description |
Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, with an increasing incidence worldwide. The treatment of PTC is currently the subject of clinical controversy, making it critically important to identify molecular markers that would help improve the risk stratification of PTC patients and optimize the therapeutic approach. The VHL tumor suppressor gene has been implicated in tumorigenesis of various types of carcinoma and linked with their aggressive biological behavior. The role of VHL in the origin and development of PTC has only recently begun to be revealed. In this narrative review we attempt to summarize the existing knowledge that implicates VHL in PTC pathogenesis and to outline its potential significance as a candidate molecular biomarker for the grouping of PTC patients into high and low risk groups.
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| first_indexed | 2024-04-24T23:39:41Z |
| format | Article |
| id | doaj.art-015c53d0a0dd49758f82a8da48a221fb |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:41Z |
| publishDate | 2023-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-015c53d0a0dd49758f82a8da48a221fb2024-03-15T13:22:45ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-01-0123110.17305/bjbms.2022.7850VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinomaLidija Todorović0https://orcid.org/0000-0003-0672-0693Boban Stanojević1https://orcid.org/0000-0002-4674-0384Laboratory for Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, SerbiaLaboratory for Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia; Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King's College London, London, UK; Virocell Biologics Ltd, London, UK Papillary thyroid carcinoma (PTC) is the most common type of endocrine cancer, with an increasing incidence worldwide. The treatment of PTC is currently the subject of clinical controversy, making it critically important to identify molecular markers that would help improve the risk stratification of PTC patients and optimize the therapeutic approach. The VHL tumor suppressor gene has been implicated in tumorigenesis of various types of carcinoma and linked with their aggressive biological behavior. The role of VHL in the origin and development of PTC has only recently begun to be revealed. In this narrative review we attempt to summarize the existing knowledge that implicates VHL in PTC pathogenesis and to outline its potential significance as a candidate molecular biomarker for the grouping of PTC patients into high and low risk groups. https://www.bjbms.org/ojs/index.php/bjbms/article/view/7850Papillary thyroid cancerPTCVHLbiomarkerrisk stratificationtumor suppressor |
| spellingShingle | Lidija Todorović Boban Stanojević VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma Biomolecules & Biomedicine Papillary thyroid cancer PTC VHL biomarker risk stratification tumor suppressor |
| title | VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma |
| title_full | VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma |
| title_fullStr | VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma |
| title_full_unstemmed | VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma |
| title_short | VHL tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma |
| title_sort | vhl tumor suppressor as a novel potential candidate biomarker in papillary thyroid carcinoma |
| topic | Papillary thyroid cancer PTC VHL biomarker risk stratification tumor suppressor |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/7850 |
| work_keys_str_mv | AT lidijatodorovic vhltumorsuppressorasanovelpotentialcandidatebiomarkerinpapillarythyroidcarcinoma AT bobanstanojevic vhltumorsuppressorasanovelpotentialcandidatebiomarkerinpapillarythyroidcarcinoma |