Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration
Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) were synthesized by a water-based sol-gel te...
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MDPI AG
2022-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/1/13 |
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| author | Mozan Hassan Mohsin Sulaiman Priya Dharshini Yuvaraju Emmanuel Galiwango Ihtesham ur Rehman Ali H. Al-Marzouqi Abbas Khaleel Sahar Mohsin |
| author_facet | Mozan Hassan Mohsin Sulaiman Priya Dharshini Yuvaraju Emmanuel Galiwango Ihtesham ur Rehman Ali H. Al-Marzouqi Abbas Khaleel Sahar Mohsin |
| author_sort | Mozan Hassan |
| collection | DOAJ |
| description | Synthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) were synthesized by a water-based sol-gel technique. Sr/Zn n-HAp and poly (lactide-co-glycolide) (PLGA) were used to fabricate composite scaffolds by supercritical carbon dioxide technique. FTIR, XRD, TEM, SEM, and TGA were used to characterize Sr/Zn n-HAp and the composite scaffolds. The synthesized scaffolds were adequately porous with an average pore size range between 189 to 406 µm. The scaffolds demonstrated bioactive behavior by forming crystals when immersed in the simulated body fluid. The scaffolds after immersing in Tris/HCl buffer increased the pH value of the medium, establishing their favorable biodegradable behavior. ICP-MS study for the scaffolds detected the presence of Sr, Ca, and Zn ions in the SBF within the first week, which would augment osseointegration if implanted in the body. nHAp and their composites (PLGA-nHAp) showed ultimate compressive strength ranging between 0.4–19.8 MPa. A 2.5% Sr/Zn substituted nHAp-PLGA composite showed a compressive behavior resembling that of cancellous bone indicating it as a good candidate for cancellous bone substitute. |
| first_indexed | 2024-03-09T19:36:09Z |
| format | Article |
| id | doaj.art-015cda4dc52f4d4ab26d8ab00df24f08 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T19:36:09Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-015cda4dc52f4d4ab26d8ab00df24f082023-11-24T01:53:27ZengMDPI AGJournal of Functional Biomaterials2079-49832022-01-011311310.3390/jfb13010013Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone RegenerationMozan Hassan0Mohsin Sulaiman1Priya Dharshini Yuvaraju2Emmanuel Galiwango3Ihtesham ur Rehman4Ali H. Al-Marzouqi5Abbas Khaleel6Sahar Mohsin7Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDepartment of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDepartment of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDepartment of Chemical and Petroleum Engineering, College of Engineering, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesEngineering Department, Faculty of Science and Technology, Lancaster University, Gillow Avenue, Lancaster LA1 4YW, UKDepartment of Chemical and Petroleum Engineering, College of Engineering, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDepartment of Chemistry, College of Science, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDepartment of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesSynthetic bone graft substitutes have attracted increasing attention in tissue engineering. This study aimed to fabricate a novel, bioactive, porous scaffold that can be used as a bone substitute. Strontium and zinc doped nano-hydroxyapatite (Sr/Zn n-HAp) were synthesized by a water-based sol-gel technique. Sr/Zn n-HAp and poly (lactide-co-glycolide) (PLGA) were used to fabricate composite scaffolds by supercritical carbon dioxide technique. FTIR, XRD, TEM, SEM, and TGA were used to characterize Sr/Zn n-HAp and the composite scaffolds. The synthesized scaffolds were adequately porous with an average pore size range between 189 to 406 µm. The scaffolds demonstrated bioactive behavior by forming crystals when immersed in the simulated body fluid. The scaffolds after immersing in Tris/HCl buffer increased the pH value of the medium, establishing their favorable biodegradable behavior. ICP-MS study for the scaffolds detected the presence of Sr, Ca, and Zn ions in the SBF within the first week, which would augment osseointegration if implanted in the body. nHAp and their composites (PLGA-nHAp) showed ultimate compressive strength ranging between 0.4–19.8 MPa. A 2.5% Sr/Zn substituted nHAp-PLGA composite showed a compressive behavior resembling that of cancellous bone indicating it as a good candidate for cancellous bone substitute.https://www.mdpi.com/2079-4983/13/1/13PLGAbone scaffoldszincstrontiumnano-hydroxyapatitesupercritical CO<sub>2</sub> |
| spellingShingle | Mozan Hassan Mohsin Sulaiman Priya Dharshini Yuvaraju Emmanuel Galiwango Ihtesham ur Rehman Ali H. Al-Marzouqi Abbas Khaleel Sahar Mohsin Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration Journal of Functional Biomaterials PLGA bone scaffolds zinc strontium nano-hydroxyapatite supercritical CO<sub>2</sub> |
| title | Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration |
| title_full | Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration |
| title_fullStr | Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration |
| title_full_unstemmed | Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration |
| title_short | Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration |
| title_sort | biomimetic plga strontium zinc nano hydroxyapatite composite scaffolds for bone regeneration |
| topic | PLGA bone scaffolds zinc strontium nano-hydroxyapatite supercritical CO<sub>2</sub> |
| url | https://www.mdpi.com/2079-4983/13/1/13 |
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