Nuclear Beclin 1 Destabilizes Retinoblastoma Protein to Promote Cell Cycle Progression and Colorectal Cancer Growth

Nuclear Beclin 1 Destabilizes Retinoblastoma Protein to Promote Cell Cycle Progression and Colorectal Cancer Growth

Autophagy is elevated in colorectal cancer (CRC) and is generally associated with poor prognosis. However, the role of autophagy core-protein Beclin 1 remains controversial in CRC development. Here, we show that the expression of nuclear Beclin 1 protein is upregulated in CRC with a negative correla...

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Bibliographic Details
Main Authors: Yang Pan, Zhiqiang Zhao, Juan Li, Jinsong Li, Yue Luo, Weiyuxin Li, Wanbang You, Yujun Zhang, Zhonghan Li, Jian Yang, Zhi-Xiong Jim Xiao, Yang Wang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
Beclin 1
retinoblastoma protein
MDMX
cell cycle
colorectal cancer
Online Access:https://www.mdpi.com/2072-6694/14/19/4735

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