What programs the size of animal cells?
The human body is programmed with definite quantities, magnitudes, and proportions. At the microscopic level, such definite sizes manifest in individual cells - different cell types are characterized by distinct cell sizes whereas cells of the same type are highly uniform in size. How do cells in a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.949382/full |
| _version_ | 1797989407658082304 |
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| author | Shixuan Liu Shixuan Liu Shixuan Liu Ceryl Tan Ceryl Tan Mike Tyers Anders Zetterberg Ran Kafri Ran Kafri |
| author_facet | Shixuan Liu Shixuan Liu Shixuan Liu Ceryl Tan Ceryl Tan Mike Tyers Anders Zetterberg Ran Kafri Ran Kafri |
| author_sort | Shixuan Liu |
| collection | DOAJ |
| description | The human body is programmed with definite quantities, magnitudes, and proportions. At the microscopic level, such definite sizes manifest in individual cells - different cell types are characterized by distinct cell sizes whereas cells of the same type are highly uniform in size. How do cells in a population maintain uniformity in cell size, and how are changes in target size programmed? A convergence of recent and historical studies suggest - just as a thermostat maintains room temperature - the size of proliferating animal cells is similarly maintained by homeostatic mechanisms. In this review, we first summarize old and new literature on the existence of cell size checkpoints, then discuss additional advances in the study of size homeostasis that involve feedback regulation of cellular growth rate. We further discuss recent progress on the molecules that underlie cell size checkpoints and mechanisms that specify target size setpoints. Lastly, we discuss a less-well explored teleological question: why does cell size matter and what is the functional importance of cell size control? |
| first_indexed | 2024-04-11T08:18:42Z |
| format | Article |
| id | doaj.art-015e989f574a41878dfab51f096e1b0c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T08:18:42Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-015e989f574a41878dfab51f096e1b0c2022-12-22T04:35:00ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-11-011010.3389/fcell.2022.949382949382What programs the size of animal cells?Shixuan Liu0Shixuan Liu1Shixuan Liu2Ceryl Tan3Ceryl Tan4Mike Tyers5Anders Zetterberg6Ran Kafri7Ran Kafri8Department of Molecular Genetics, University of Toronto, Toronto, ON, CanadaProgram in Cell Biology, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA, United StatesDepartment of Molecular Genetics, University of Toronto, Toronto, ON, CanadaProgram in Cell Biology, The Hospital for Sick Children, Toronto, ON, CanadaInstitute for Research in Immunology and Cancer, University of Montréal, Montréal, QC, CanadaDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, SwedenDepartment of Molecular Genetics, University of Toronto, Toronto, ON, CanadaProgram in Cell Biology, The Hospital for Sick Children, Toronto, ON, CanadaThe human body is programmed with definite quantities, magnitudes, and proportions. At the microscopic level, such definite sizes manifest in individual cells - different cell types are characterized by distinct cell sizes whereas cells of the same type are highly uniform in size. How do cells in a population maintain uniformity in cell size, and how are changes in target size programmed? A convergence of recent and historical studies suggest - just as a thermostat maintains room temperature - the size of proliferating animal cells is similarly maintained by homeostatic mechanisms. In this review, we first summarize old and new literature on the existence of cell size checkpoints, then discuss additional advances in the study of size homeostasis that involve feedback regulation of cellular growth rate. We further discuss recent progress on the molecules that underlie cell size checkpoints and mechanisms that specify target size setpoints. Lastly, we discuss a less-well explored teleological question: why does cell size matter and what is the functional importance of cell size control?https://www.frontiersin.org/articles/10.3389/fcell.2022.949382/fullcell sizecell size checkpointcell cyclecell size homeostasiscell growthtarget size |
| spellingShingle | Shixuan Liu Shixuan Liu Shixuan Liu Ceryl Tan Ceryl Tan Mike Tyers Anders Zetterberg Ran Kafri Ran Kafri What programs the size of animal cells? Frontiers in Cell and Developmental Biology cell size cell size checkpoint cell cycle cell size homeostasis cell growth target size |
| title | What programs the size of animal cells? |
| title_full | What programs the size of animal cells? |
| title_fullStr | What programs the size of animal cells? |
| title_full_unstemmed | What programs the size of animal cells? |
| title_short | What programs the size of animal cells? |
| title_sort | what programs the size of animal cells |
| topic | cell size cell size checkpoint cell cycle cell size homeostasis cell growth target size |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.949382/full |
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