The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study
Abstract Background Multiple evanescent white dot syndrome (MEWDS)-like features is a rare condition triggered by a macular disease or iatrogenic injury, exhibiting MEWDS changes in the fundus. This study aims to describe the multimodal imaging features and outcomes of multifocal choroiditis/punctat...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-03277-6 |
| _version_ | 1797363480715591680 |
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| author | Chunli Chen Yizhe Cheng Zhihan Zhang Yang Zhang Simeng Hou Ge Wang Xiaoyan Peng |
| author_facet | Chunli Chen Yizhe Cheng Zhihan Zhang Yang Zhang Simeng Hou Ge Wang Xiaoyan Peng |
| author_sort | Chunli Chen |
| collection | DOAJ |
| description | Abstract Background Multiple evanescent white dot syndrome (MEWDS)-like features is a rare condition triggered by a macular disease or iatrogenic injury, exhibiting MEWDS changes in the fundus. This study aims to describe the multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy (MFC/PIC) lesions with MEWDS-like features. Methods Six cases were studied retrospectively. All cases were given regional and oral corticosteroids. Results All cases showed an isolated juxtafoveal yellowish-white MFC/PIC lesion with disruption of RPE-Bruch’s membrane-choriocapillaris complex (RPE-BM-CC), subretinal hyperreflective materials and choroidal thickening on optical coherence tomography. Two weeks after presentation, the grayish-white dots disappeared spontaneously and the corticosteroids were given. After four weeks, the ellipsoid zone (EZ) around the lesion and hyper-autofluorescence resolved. After 13 weeks, five cases showed shrinkage of the juxtafoveal lesion and restoration of foveal EZ. After six months, the juxtafoveal lesion became pigmented. Only one case developed type 2 choroidal neovascularization. Conclusions The clinical course of MEWDS-like manifestations is still evanescent in our cases. The yellowish-white juxtafoveal MFC/PIC lesions with disruption of RPE-BM-CC and choroidal thickening showed a well-controlled prognosis after corticosteroid treatment. |
| first_indexed | 2024-03-08T16:21:58Z |
| format | Article |
| id | doaj.art-015e9bd1b97c46fc9f403eae518bf482 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-08T16:21:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-015e9bd1b97c46fc9f403eae518bf4822024-01-07T12:16:57ZengBMCBMC Ophthalmology1471-24152024-01-0124111310.1186/s12886-023-03277-6The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective studyChunli Chen0Yizhe Cheng1Zhihan Zhang2Yang Zhang3Simeng Hou4Ge Wang5Xiaoyan Peng6Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Beijing Tongren Hospital, Capital Medical UniversityAbstract Background Multiple evanescent white dot syndrome (MEWDS)-like features is a rare condition triggered by a macular disease or iatrogenic injury, exhibiting MEWDS changes in the fundus. This study aims to describe the multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy (MFC/PIC) lesions with MEWDS-like features. Methods Six cases were studied retrospectively. All cases were given regional and oral corticosteroids. Results All cases showed an isolated juxtafoveal yellowish-white MFC/PIC lesion with disruption of RPE-Bruch’s membrane-choriocapillaris complex (RPE-BM-CC), subretinal hyperreflective materials and choroidal thickening on optical coherence tomography. Two weeks after presentation, the grayish-white dots disappeared spontaneously and the corticosteroids were given. After four weeks, the ellipsoid zone (EZ) around the lesion and hyper-autofluorescence resolved. After 13 weeks, five cases showed shrinkage of the juxtafoveal lesion and restoration of foveal EZ. After six months, the juxtafoveal lesion became pigmented. Only one case developed type 2 choroidal neovascularization. Conclusions The clinical course of MEWDS-like manifestations is still evanescent in our cases. The yellowish-white juxtafoveal MFC/PIC lesions with disruption of RPE-BM-CC and choroidal thickening showed a well-controlled prognosis after corticosteroid treatment.https://doi.org/10.1186/s12886-023-03277-6Multifocal choroiditis/punctate inner choroidopathyMultiple evanescent white dot syndromeMultimodal imagingFocal choroidal excavationChoroidal neovascularization |
| spellingShingle | Chunli Chen Yizhe Cheng Zhihan Zhang Yang Zhang Simeng Hou Ge Wang Xiaoyan Peng The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study BMC Ophthalmology Multifocal choroiditis/punctate inner choroidopathy Multiple evanescent white dot syndrome Multimodal imaging Focal choroidal excavation Choroidal neovascularization |
| title | The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study |
| title_full | The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study |
| title_fullStr | The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study |
| title_full_unstemmed | The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study |
| title_short | The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study |
| title_sort | multimodal imaging features and outcomes of multifocal choroiditis punctate inner choroidopathy lesion with multiple evanescent white dot syndrome like features a retrospective study |
| topic | Multifocal choroiditis/punctate inner choroidopathy Multiple evanescent white dot syndrome Multimodal imaging Focal choroidal excavation Choroidal neovascularization |
| url | https://doi.org/10.1186/s12886-023-03277-6 |
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