1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents
The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator – pralidoxime. On the ot...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2004-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/47/3/0167/ |
| _version_ | 1818545859643572224 |
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| author | Kamil Kuča Vlastimil Dohnal |
| author_facet | Kamil Kuča Vlastimil Dohnal |
| author_sort | Kamil Kuča |
| collection | DOAJ |
| description | The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator – pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10–4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10–1 M (for cyclosarin) and 10–3 M (for VX) but these concentrations are not available for the use in vivo. |
| first_indexed | 2024-12-12T07:45:31Z |
| format | Article |
| id | doaj.art-015f34a3e4294c2f86bfd82aa7acfd40 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-12-12T07:45:31Z |
| publishDate | 2004-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-015f34a3e4294c2f86bfd82aa7acfd402022-12-22T00:32:37ZengKarolinum PressActa Medica1211-42861805-96942004-01-0147316716910.14712/18059694.2018.851,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve AgentsKamil Kuča0Vlastimil Dohnal1Purkyně Medical Military Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech RepublicMasaryk University in Brno, Faculty of Science, Department of Analytic Chemistry, Brno, Czech RepublicThe oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator – pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10–4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10–1 M (for cyclosarin) and 10–3 M (for VX) but these concentrations are not available for the use in vivo.https://actamedica.lfhk.cuni.cz/47/3/0167/AcetylcholinesteraseReactivationInhibitionOximesReactivatorPralidoxime |
| spellingShingle | Kamil Kuča Vlastimil Dohnal 1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents Acta Medica Acetylcholinesterase Reactivation Inhibition Oximes Reactivator Pralidoxime |
| title | 1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents |
| title_full | 1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents |
| title_fullStr | 1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents |
| title_full_unstemmed | 1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents |
| title_short | 1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents |
| title_sort | 1 3 bis 2 hydroxyiminomethylpyridinium propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents |
| topic | Acetylcholinesterase Reactivation Inhibition Oximes Reactivator Pralidoxime |
| url | https://actamedica.lfhk.cuni.cz/47/3/0167/ |
| work_keys_str_mv | AT kamilkuca 13bis2hydroxyiminomethylpyridiniumpropaneasthepotentialreactivatoroftheacetylcholinesteraseinhibitedbynerveagents AT vlastimildohnal 13bis2hydroxyiminomethylpyridiniumpropaneasthepotentialreactivatoroftheacetylcholinesteraseinhibitedbynerveagents |