Species diversity regarding the presence of proximal tubular progenitor cells of the kidney
<p>The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-02-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | http://www.ejh.it/index.php/ejh/article/view/2567 |
| _version_ | 1818146470736429056 |
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| author | J. Hansson A.E. Ericsson H. Axelson M.E. Johansson |
| author_facet | J. Hansson A.E. Ericsson H. Axelson M.E. Johansson |
| author_sort | J. Hansson |
| collection | DOAJ |
| description | <p>The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.</p> |
| first_indexed | 2024-12-11T12:19:52Z |
| format | Article |
| id | doaj.art-016047eca86348ae8a030849f12bb363 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-11T12:19:52Z |
| publishDate | 2016-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-016047eca86348ae8a030849f12bb3632022-12-22T01:07:34ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062016-02-0160110.4081/ejh.2016.25671494Species diversity regarding the presence of proximal tubular progenitor cells of the kidneyJ. Hansson0A.E. Ericsson1H. Axelson2M.E. Johansson3Lund UniversityAstra-Zeneca R&D Mölndal, CKD, Bioscience HB258Lund UniversityLund University, Skåne University Hospital<p>The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.</p>http://www.ejh.it/index.php/ejh/article/view/2567Acute tubular necrosistubular regenerationspecies diversity, proximal tubules. |
| spellingShingle | J. Hansson A.E. Ericsson H. Axelson M.E. Johansson Species diversity regarding the presence of proximal tubular progenitor cells of the kidney European Journal of Histochemistry Acute tubular necrosis tubular regeneration species diversity , proximal tubules. |
| title | Species diversity regarding the presence of proximal tubular progenitor cells of the kidney |
| title_full | Species diversity regarding the presence of proximal tubular progenitor cells of the kidney |
| title_fullStr | Species diversity regarding the presence of proximal tubular progenitor cells of the kidney |
| title_full_unstemmed | Species diversity regarding the presence of proximal tubular progenitor cells of the kidney |
| title_short | Species diversity regarding the presence of proximal tubular progenitor cells of the kidney |
| title_sort | species diversity regarding the presence of proximal tubular progenitor cells of the kidney |
| topic | Acute tubular necrosis tubular regeneration species diversity , proximal tubules. |
| url | http://www.ejh.it/index.php/ejh/article/view/2567 |
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