Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis
The concentration of water-soluble vitamins (except folic acid and vitamin B<sub>12</sub>) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD pa...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/2/440 |
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| author | Małgorzata Kaczkan Sylwia Czaja-Stolc Małgorzata Szczuko Arleta Drozd Przemysław Rutkowski Alicja Dębska-Ślizień Sylwia Małgorzewicz |
| author_facet | Małgorzata Kaczkan Sylwia Czaja-Stolc Małgorzata Szczuko Arleta Drozd Przemysław Rutkowski Alicja Dębska-Ślizień Sylwia Małgorzewicz |
| author_sort | Małgorzata Kaczkan |
| collection | DOAJ |
| description | The concentration of water-soluble vitamins (except folic acid and vitamin B<sub>12</sub>) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B<sub>1</sub>, B<sub>6</sub>, and B<sub>12</sub> levels were significantly lower in the HD group than in the control group (<i>p</i> < 0.001). Vitamin B<sub>1</sub> and B<sub>2</sub> were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; <i>p</i> < 0.05). Vitamin B<sub>3</sub>, B<sub>12</sub>, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; <i>p</i> < 0.05). Among diabetic patients, only the concentration of vitamin B<sub>1</sub> was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients. |
| first_indexed | 2024-03-09T11:30:09Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:30:09Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-01610c56990541b4a3b2d3428f5819c42023-11-30T23:51:47ZengMDPI AGNutrients2072-66432023-01-0115244010.3390/nu15020440Water-Soluble Vitamins Status in Patients Undergoing Maintenance HemodialysisMałgorzata Kaczkan0Sylwia Czaja-Stolc1Małgorzata Szczuko2Arleta Drozd3Przemysław Rutkowski4Alicja Dębska-Ślizień5Sylwia Małgorzewicz6Department of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, PolandDepartment of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Internal and Pediatric Nursing, Medical University of Gdansk, 80-210 Gdańsk, PolandDepartment of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 80-952 Gdańsk, PolandDepartment of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, PolandThe concentration of water-soluble vitamins (except folic acid and vitamin B<sub>12</sub>) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B<sub>1</sub>, B<sub>6</sub>, and B<sub>12</sub> levels were significantly lower in the HD group than in the control group (<i>p</i> < 0.001). Vitamin B<sub>1</sub> and B<sub>2</sub> were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; <i>p</i> < 0.05). Vitamin B<sub>3</sub>, B<sub>12</sub>, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; <i>p</i> < 0.05). Among diabetic patients, only the concentration of vitamin B<sub>1</sub> was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients.https://www.mdpi.com/2072-6643/15/2/440hemodialysiswater-soluble vitaminsdiabetes mellitus |
| spellingShingle | Małgorzata Kaczkan Sylwia Czaja-Stolc Małgorzata Szczuko Arleta Drozd Przemysław Rutkowski Alicja Dębska-Ślizień Sylwia Małgorzewicz Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis Nutrients hemodialysis water-soluble vitamins diabetes mellitus |
| title | Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis |
| title_full | Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis |
| title_fullStr | Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis |
| title_full_unstemmed | Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis |
| title_short | Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis |
| title_sort | water soluble vitamins status in patients undergoing maintenance hemodialysis |
| topic | hemodialysis water-soluble vitamins diabetes mellitus |
| url | https://www.mdpi.com/2072-6643/15/2/440 |
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