METTL3 mediates SOX5 m6A methylation in bronchial epithelial cells to attenuate Th2 cell differentiation in T2 asthma

METTL3 mediates SOX5 m6A methylation in bronchial epithelial cells to attenuate Th2 cell differentiation in T2 asthma

Objective: Asthma, a chronic inflammatory disease in which type 2 T helper cells (Th2) play a causative role in the development of T2 asthma. N6-methyladenosine (m6A) modification, an mRNA modification, and methyltransferase-like 3 (METTL3) is involved in the development of T2 asthma by inhibiting T...

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Bibliographic Details
Main Authors: Zhifeng Chen, Yulin Shang, Xiufeng Zhang, Wentao Duan, Jianmin Li, Liming Zhu, Libing Ma, Xudong Xiang, Jingsi Jia, Xiaoying Ji, Subo Gong
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Heliyon
Subjects:
T2 asthma
m6A
METTL3
SOX5
HBE cells
Th2
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024049156

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