Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions

Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions

Three decades of research have documented the spatiotemporal dynamics of RHO family GTPase membrane extraction regulated by guanine nucleotide dissociation inhibitors (GDIs), but the interplay of the kinetic mechanism and structural specificity of these interactions is as yet unresolved. To address...

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Bibliographic Details
Main Authors: Niloufar Mosaddeghzadeh, Neda S. Kazemein Jasemi, Jisca Majolée, Si-Cai Zhang, Peter L. Hordijk, Radovan Dvorsky, Mohammad Reza Ahmadian
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
CDC42
electrostatic steering
G domain
hypervariable region
geranylgeranyl
guanine nucleotide dissociation inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/22/12493

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https://www.mdpi.com/1422-0067/22/22/12493

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