Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System
Quercetin is a dietary flavonoid present in vegetables, fruits, and beverages, such as onions, apples, broccoli, berries, citrus fruits, tea, and red wine. Flavonoids have antioxidant and anti-inflammatory effects, acting in the prevention of several diseases. Quercetin also has neuroprotective prop...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/1/149 |
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| author | Simone Ortiz Moura Fideles Adriana de Cássia Ortiz Daniela Vieira Buchaim Eliana de Souza Bastos Mazuqueli Pereira Maria Júlia Bento Martins Parreira Jéssica de Oliveira Rossi Marcelo Rodrigues da Cunha Alexandre Teixeira de Souza Wendel Cleber Soares Rogerio Leone Buchaim |
| author_facet | Simone Ortiz Moura Fideles Adriana de Cássia Ortiz Daniela Vieira Buchaim Eliana de Souza Bastos Mazuqueli Pereira Maria Júlia Bento Martins Parreira Jéssica de Oliveira Rossi Marcelo Rodrigues da Cunha Alexandre Teixeira de Souza Wendel Cleber Soares Rogerio Leone Buchaim |
| author_sort | Simone Ortiz Moura Fideles |
| collection | DOAJ |
| description | Quercetin is a dietary flavonoid present in vegetables, fruits, and beverages, such as onions, apples, broccoli, berries, citrus fruits, tea, and red wine. Flavonoids have antioxidant and anti-inflammatory effects, acting in the prevention of several diseases. Quercetin also has neuroprotective properties and may exert a beneficial effect on nervous tissue. In this literature review, we compiled in vivo studies that investigated the effect of quercetin on regeneration and functional recovery of the central and peripheral nervous system. In spinal cord injuries (SCI), quercetin administration favored axonal regeneration and recovery of locomotor capacity, significantly improving electrophysiological parameters. Quercetin reduced edema, neutrophil infiltration, cystic cavity formation, reactive oxygen species production, and pro-inflammatory cytokine synthesis, while favoring an increase in levels of anti-inflammatory cytokines, minimizing tissue damage in SCI models. In addition, the association of quercetin with mesenchymal stromal cells transplantation had a synergistic neuroprotective effect on spinal cord injury. Similarly, in sciatic nerve injuries, quercetin favored and accelerated sensory and motor recovery, reducing muscle atrophy. In these models, quercetin significantly inhibited oxidative stress and cell apoptosis, favoring Schwann cell proliferation and nerve fiber remyelination, thus promoting a significant increase in the number and diameter of myelinated fibers. Although there is still a lack of clinical research, in vivo studies have shown that quercetin contributed to the recovery of neurological functions, exerting a beneficial effect on the regeneration of the central and peripheral nervous system. |
| first_indexed | 2024-03-09T13:45:47Z |
| format | Article |
| id | doaj.art-016aee00ebb84cd8b6d550adf9b67165 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:45:47Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-016aee00ebb84cd8b6d550adf9b671652023-11-30T20:59:00ZengMDPI AGAntioxidants2076-39212023-01-0112114910.3390/antiox12010149Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous SystemSimone Ortiz Moura Fideles0Adriana de Cássia Ortiz1Daniela Vieira Buchaim2Eliana de Souza Bastos Mazuqueli Pereira3Maria Júlia Bento Martins Parreira4Jéssica de Oliveira Rossi5Marcelo Rodrigues da Cunha6Alexandre Teixeira de Souza7Wendel Cleber Soares8Rogerio Leone Buchaim9Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia (UNIMAR), Marília 17525-902, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilGraduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, BrazilAnatomy Department, Padre Anchieta University Center (UniAnchieta), Jundiai 13210-795, BrazilDepartment of Medicine, University Center of Adamantina (UNIFAI), Adamantina 17800-000, BrazilDepartment of Exact Sciences, University Center of Adamantina (UNIFAI), Adamantina 17800-000, BrazilDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, BrazilQuercetin is a dietary flavonoid present in vegetables, fruits, and beverages, such as onions, apples, broccoli, berries, citrus fruits, tea, and red wine. Flavonoids have antioxidant and anti-inflammatory effects, acting in the prevention of several diseases. Quercetin also has neuroprotective properties and may exert a beneficial effect on nervous tissue. In this literature review, we compiled in vivo studies that investigated the effect of quercetin on regeneration and functional recovery of the central and peripheral nervous system. In spinal cord injuries (SCI), quercetin administration favored axonal regeneration and recovery of locomotor capacity, significantly improving electrophysiological parameters. Quercetin reduced edema, neutrophil infiltration, cystic cavity formation, reactive oxygen species production, and pro-inflammatory cytokine synthesis, while favoring an increase in levels of anti-inflammatory cytokines, minimizing tissue damage in SCI models. In addition, the association of quercetin with mesenchymal stromal cells transplantation had a synergistic neuroprotective effect on spinal cord injury. Similarly, in sciatic nerve injuries, quercetin favored and accelerated sensory and motor recovery, reducing muscle atrophy. In these models, quercetin significantly inhibited oxidative stress and cell apoptosis, favoring Schwann cell proliferation and nerve fiber remyelination, thus promoting a significant increase in the number and diameter of myelinated fibers. Although there is still a lack of clinical research, in vivo studies have shown that quercetin contributed to the recovery of neurological functions, exerting a beneficial effect on the regeneration of the central and peripheral nervous system.https://www.mdpi.com/2076-3921/12/1/149quercetinnerve regenerationnervous systemspinal cordperipheral nerves |
| spellingShingle | Simone Ortiz Moura Fideles Adriana de Cássia Ortiz Daniela Vieira Buchaim Eliana de Souza Bastos Mazuqueli Pereira Maria Júlia Bento Martins Parreira Jéssica de Oliveira Rossi Marcelo Rodrigues da Cunha Alexandre Teixeira de Souza Wendel Cleber Soares Rogerio Leone Buchaim Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System Antioxidants quercetin nerve regeneration nervous system spinal cord peripheral nerves |
| title | Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System |
| title_full | Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System |
| title_fullStr | Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System |
| title_full_unstemmed | Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System |
| title_short | Influence of the Neuroprotective Properties of Quercetin on Regeneration and Functional Recovery of the Nervous System |
| title_sort | influence of the neuroprotective properties of quercetin on regeneration and functional recovery of the nervous system |
| topic | quercetin nerve regeneration nervous system spinal cord peripheral nerves |
| url | https://www.mdpi.com/2076-3921/12/1/149 |
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