Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis
In the United States and Europe, gastroesophageal reflux (GER) is receiving attention as a potential cause of bronchial asthma. Few Japanese case reports have described this relationship. Therefore, we investigated the effect of omeprazole and cisapride on pulmonary function tests, blood gases and h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1997-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015315951 |
| _version_ | 1818878256219160576 |
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| author | Katsuya Fujimori Eiichi Suzuki Masaaki Arakawa |
| author_facet | Katsuya Fujimori Eiichi Suzuki Masaaki Arakawa |
| author_sort | Katsuya Fujimori |
| collection | DOAJ |
| description | In the United States and Europe, gastroesophageal reflux (GER) is receiving attention as a potential cause of bronchial asthma. Few Japanese case reports have described this relationship. Therefore, we investigated the effect of omeprazole and cisapride on pulmonary function tests, blood gases and home peak expiratory flow rates (PEFR) in six Japanese outpatients with asthma and proven GER. After 8 weeks of treatment, reflux esophagitis had improved in all patients. However, the parameters of pulmonary function showed no change other than a significant post- treatment increase in home PEFR (4.4-27.7%) in three patients. These results suggest that anti-reflux (omeprazole and cisapride) treatment will produce small improvements in the PEFR in some Japanese asthmatics with GER. |
| first_indexed | 2024-12-19T14:11:17Z |
| format | Article |
| id | doaj.art-016ba9df27f64867a592edc6dd12e824 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-19T14:11:17Z |
| publishDate | 1997-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-016ba9df27f64867a592edc6dd12e8242022-12-21T20:18:07ZengElsevierAllergology International1323-89301997-01-0146316717210.2332/allergolint.46.167Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitisKatsuya Fujimori0Eiichi Suzuki1Masaaki Arakawa2Department of Internal Medicine, Niigata Prefectural Shibata Hospital, Shibata, JapanDepartment of Medicine (II), Niigata University School of Medicine, Niigata, JapanDepartment of Medicine (II), Niigata University School of Medicine, Niigata, JapanIn the United States and Europe, gastroesophageal reflux (GER) is receiving attention as a potential cause of bronchial asthma. Few Japanese case reports have described this relationship. Therefore, we investigated the effect of omeprazole and cisapride on pulmonary function tests, blood gases and home peak expiratory flow rates (PEFR) in six Japanese outpatients with asthma and proven GER. After 8 weeks of treatment, reflux esophagitis had improved in all patients. However, the parameters of pulmonary function showed no change other than a significant post- treatment increase in home PEFR (4.4-27.7%) in three patients. These results suggest that anti-reflux (omeprazole and cisapride) treatment will produce small improvements in the PEFR in some Japanese asthmatics with GER.http://www.sciencedirect.com/science/article/pii/S1323893015315951bronchial asthmacisapridegastroesophageal refluxJapaneseomeprazolereflux esophagitis |
| spellingShingle | Katsuya Fujimori Eiichi Suzuki Masaaki Arakawa Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis Allergology International bronchial asthma cisapride gastroesophageal reflux Japanese omeprazole reflux esophagitis |
| title | Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis |
| title_full | Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis |
| title_fullStr | Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis |
| title_full_unstemmed | Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis |
| title_short | Effects of omeprazole and cisapride treatment in Japanese asthmatics with reflux esophagitis |
| title_sort | effects of omeprazole and cisapride treatment in japanese asthmatics with reflux esophagitis |
| topic | bronchial asthma cisapride gastroesophageal reflux Japanese omeprazole reflux esophagitis |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015315951 |
| work_keys_str_mv | AT katsuyafujimori effectsofomeprazoleandcisapridetreatmentinjapaneseasthmaticswithrefluxesophagitis AT eiichisuzuki effectsofomeprazoleandcisapridetreatmentinjapaneseasthmaticswithrefluxesophagitis AT masaakiarakawa effectsofomeprazoleandcisapridetreatmentinjapaneseasthmaticswithrefluxesophagitis |