Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents
Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer. These lithium-based substances have a lot of potential properties because of the anionic...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2018;volume=10;issue=4;spage=240;epage=245;aulast=Plotnikov |
| _version_ | 1819092921095290880 |
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| author | Evgenii Plotnikov Elena Korotkova Olesya Voronova |
| author_facet | Evgenii Plotnikov Elena Korotkova Olesya Voronova |
| author_sort | Evgenii Plotnikov |
| collection | DOAJ |
| description | Objective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer. These lithium-based substances have a lot of potential properties because of the anionic component of the Krebs cycle substrates, which take part in basic intracellular biochemical process. Materials and Methods: Lithium salts of fumarate, pyruvate, malate, succinate, and citrate (as reference drug) were investigated in this study as antioxidants and immunomodulators. The antioxidant properties were studied by the voltammetry method, which evaluates oxygen radical scavenging capacity of lithium substances. Influence of the lithium compounds on the immune cells of human blood was indicated by the reaction of blast transformation of lymphocytes. Results: All tested substances and their mixes possessed antioxidant properties, more expressed in maximal therapeutic concentration. Lithium compounds showed no toxic influence on human blood immune cells and caused no significant changes in both spontaneous and stimulated proliferation. Conclusion: The results allow considering lithium salts of Krebs cycle substrates as potential normothymic agents (mood stabilizer) with antioxidant properties and low toxicity. |
| first_indexed | 2024-12-21T23:03:17Z |
| format | Article |
| id | doaj.art-016c25f306b64269a8e31e27dece40a2 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-21T23:03:17Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-016c25f306b64269a8e31e27dece40a22022-12-21T18:47:14ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062018-01-0110424024510.4103/JPBS.JPBS_140_18Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agentsEvgenii PlotnikovElena KorotkovaOlesya VoronovaObjective: Aim of the present work was to study the antioxidant properties of lithium salts of Krebs cycle substrates and their influence on immune cells. Lithium is a well-known and widely used mood stabilizer. These lithium-based substances have a lot of potential properties because of the anionic component of the Krebs cycle substrates, which take part in basic intracellular biochemical process. Materials and Methods: Lithium salts of fumarate, pyruvate, malate, succinate, and citrate (as reference drug) were investigated in this study as antioxidants and immunomodulators. The antioxidant properties were studied by the voltammetry method, which evaluates oxygen radical scavenging capacity of lithium substances. Influence of the lithium compounds on the immune cells of human blood was indicated by the reaction of blast transformation of lymphocytes. Results: All tested substances and their mixes possessed antioxidant properties, more expressed in maximal therapeutic concentration. Lithium compounds showed no toxic influence on human blood immune cells and caused no significant changes in both spontaneous and stimulated proliferation. Conclusion: The results allow considering lithium salts of Krebs cycle substrates as potential normothymic agents (mood stabilizer) with antioxidant properties and low toxicity.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2018;volume=10;issue=4;spage=240;epage=245;aulast=PlotnikovAntioxidantfumarateKrebs cyclelithium ionsmalatepyruvatesuccinate |
| spellingShingle | Evgenii Plotnikov Elena Korotkova Olesya Voronova Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents Journal of Pharmacy and Bioallied Sciences Antioxidant fumarate Krebs cycle lithium ions malate pyruvate succinate |
| title | Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents |
| title_full | Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents |
| title_fullStr | Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents |
| title_full_unstemmed | Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents |
| title_short | Lithium salts of Krebs cycle substrates as potential normothymic antioxidant agents |
| title_sort | lithium salts of krebs cycle substrates as potential normothymic antioxidant agents |
| topic | Antioxidant fumarate Krebs cycle lithium ions malate pyruvate succinate |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2018;volume=10;issue=4;spage=240;epage=245;aulast=Plotnikov |
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