Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis
Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is a tightly packed layer of endothelial cells that shields the brain from harmful substances in the blood, allowing necessary nutrients to pass through. It...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/11/2599 |
| _version_ | 1827638951897202688 |
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| author | Sarfaraz K. Niazi |
| author_facet | Sarfaraz K. Niazi |
| author_sort | Sarfaraz K. Niazi |
| collection | DOAJ |
| description | Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is a tightly packed layer of endothelial cells that shields the brain from harmful substances in the blood, allowing necessary nutrients to pass through. It is a highly selective barrier, which poses a challenge to delivering therapeutic agents into the brain. Several non-invasive procedures and devices have been developed or are currently being investigated to enhance drug delivery across the BBB. This paper presents a review and a prospective analysis of the art and science that address pharmacology, technology, delivery systems, regulatory approval, ethical concerns, and future possibilities. |
| first_indexed | 2024-03-09T16:30:59Z |
| format | Article |
| id | doaj.art-016f363e31a44f00bc2fd222cb230690 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T16:30:59Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-016f363e31a44f00bc2fd222cb2306902023-11-24T15:01:04ZengMDPI AGPharmaceutics1999-49232023-11-011511259910.3390/pharmaceutics15112599Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective AnalysisSarfaraz K. Niazi0College of Pharmacy, University of Illinois, Chicago, IL 60612, USANon-invasive drug delivery across the blood–brain barrier (BBB) represents a significant advancement in treating neurological diseases. The BBB is a tightly packed layer of endothelial cells that shields the brain from harmful substances in the blood, allowing necessary nutrients to pass through. It is a highly selective barrier, which poses a challenge to delivering therapeutic agents into the brain. Several non-invasive procedures and devices have been developed or are currently being investigated to enhance drug delivery across the BBB. This paper presents a review and a prospective analysis of the art and science that address pharmacology, technology, delivery systems, regulatory approval, ethical concerns, and future possibilities.https://www.mdpi.com/1999-4923/15/11/2599neurodegenerative disordersblood–brain barriernon-invasive deliverydevice-related deliveryAlzheimer’s diseaseParkinson’s disease |
| spellingShingle | Sarfaraz K. Niazi Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis Pharmaceutics neurodegenerative disorders blood–brain barrier non-invasive delivery device-related delivery Alzheimer’s disease Parkinson’s disease |
| title | Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis |
| title_full | Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis |
| title_fullStr | Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis |
| title_full_unstemmed | Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis |
| title_short | Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis |
| title_sort | non invasive drug delivery across the blood brain barrier a prospective analysis |
| topic | neurodegenerative disorders blood–brain barrier non-invasive delivery device-related delivery Alzheimer’s disease Parkinson’s disease |
| url | https://www.mdpi.com/1999-4923/15/11/2599 |
| work_keys_str_mv | AT sarfarazkniazi noninvasivedrugdeliveryacrossthebloodbrainbarrieraprospectiveanalysis |