Crosstalk between protein post-translational modifications and phase separation
Abstract The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the tendency of phase separation has some l...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01380-1 |
| _version_ | 1797273785972293632 |
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| author | Yang Liu Wenjuan Feng Yunshan Wang Bin Wu |
| author_facet | Yang Liu Wenjuan Feng Yunshan Wang Bin Wu |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Abstract The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the tendency of phase separation has some limitations. Here we focus on several post-translational modifications of proteins, including protein phosphorylation modification at multiple sites, methylation modification, acetylation modification, ubiquitination modification, SUMOylation modification, etc., which regulate the formation of phase separation and the stability of phase separation structure through multivalent interactions. This regulatory role is closely related to the development of neurodegenerative diseases, tumors, viral infections, and other diseases, and also plays essential functions in environmental stress, DNA damage repair, transcriptional regulation, signal transduction, and cell homeostasis of living organisms, which provides an idea to explore the interaction between novel protein post-translational modifications and phase separation. Video Abstract |
| first_indexed | 2024-03-07T14:49:11Z |
| format | Article |
| id | doaj.art-016f603ac2ee4ed0b76d42e9e4710fee |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-07T14:49:11Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-016f603ac2ee4ed0b76d42e9e4710fee2024-03-05T19:46:55ZengBMCCell Communication and Signaling1478-811X2024-02-0122111510.1186/s12964-023-01380-1Crosstalk between protein post-translational modifications and phase separationYang Liu0Wenjuan Feng1Yunshan Wang2Bin Wu3Jinan Central Hospital, Cheeloo College of Medicine, Shandong UniversityDepartment of Reproductive Medicine, Central Hospital Affiliated to Shandong First Medical UniversityJinan Central Hospital, Cheeloo College of Medicine, Shandong UniversityJinan Central Hospital, Cheeloo College of Medicine, Shandong UniversityAbstract The phenomenon of phase separation is quite common in cells, and it is involved in multiple processes of life activities. However, the current research on the correlation between protein modifications and phase separation and the interference with the tendency of phase separation has some limitations. Here we focus on several post-translational modifications of proteins, including protein phosphorylation modification at multiple sites, methylation modification, acetylation modification, ubiquitination modification, SUMOylation modification, etc., which regulate the formation of phase separation and the stability of phase separation structure through multivalent interactions. This regulatory role is closely related to the development of neurodegenerative diseases, tumors, viral infections, and other diseases, and also plays essential functions in environmental stress, DNA damage repair, transcriptional regulation, signal transduction, and cell homeostasis of living organisms, which provides an idea to explore the interaction between novel protein post-translational modifications and phase separation. Video Abstracthttps://doi.org/10.1186/s12964-023-01380-1Phase separationPost-translational modificationsBiomolecular condensatesNeurodegenerative DiseasesTumorsViral Infections |
| spellingShingle | Yang Liu Wenjuan Feng Yunshan Wang Bin Wu Crosstalk between protein post-translational modifications and phase separation Cell Communication and Signaling Phase separation Post-translational modifications Biomolecular condensates Neurodegenerative Diseases Tumors Viral Infections |
| title | Crosstalk between protein post-translational modifications and phase separation |
| title_full | Crosstalk between protein post-translational modifications and phase separation |
| title_fullStr | Crosstalk between protein post-translational modifications and phase separation |
| title_full_unstemmed | Crosstalk between protein post-translational modifications and phase separation |
| title_short | Crosstalk between protein post-translational modifications and phase separation |
| title_sort | crosstalk between protein post translational modifications and phase separation |
| topic | Phase separation Post-translational modifications Biomolecular condensates Neurodegenerative Diseases Tumors Viral Infections |
| url | https://doi.org/10.1186/s12964-023-01380-1 |
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