Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are crit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1084759/full |
| _version_ | 1797844970702372864 |
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| author | Adrienne K. Scott Michael Rafuse Corey P. Neu Corey P. Neu Corey P. Neu |
| author_facet | Adrienne K. Scott Michael Rafuse Corey P. Neu Corey P. Neu Corey P. Neu |
| author_sort | Adrienne K. Scott |
| collection | DOAJ |
| description | Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are critical environmental cues that influence phenotypic plasticity and stability. Furthermore, an exposure to a prior mechanical signal has been demonstrated to play a fundamental role in modulating phenotypic changes that persist even after the mechanical stimulus is removed, creating stable mechanical memories. In this mini review, our objective is to highlight how the mechanical environment alters both phenotypic plasticity and stable memories through changes in chromatin architecture, mainly focusing on examples in cardiac tissue. We first explore how cell phenotypic plasticity is modulated in response to changes in the mechanical environment, and then connect the changes in phenotypic plasticity to changes in chromatin architecture that reflect short-term and long-term memories. Finally, we discuss how elucidating the mechanisms behind mechanically induced chromatin architecture that lead to cell adaptations and retention of stable mechanical memories could uncover treatment methods to prevent mal-adaptive permanent disease states. |
| first_indexed | 2024-04-09T17:30:59Z |
| format | Article |
| id | doaj.art-01710117b99c4759afd0cb3f49868285 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T17:30:59Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-01710117b99c4759afd0cb3f498682852023-04-18T05:09:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-04-011110.3389/fcell.2023.10847591084759Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memoryAdrienne K. Scott0Michael Rafuse1Corey P. Neu2Corey P. Neu3Corey P. Neu4Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United StatesPaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United StatesPaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, United StatesBiomedical Engineering Program, University of Colorado Boulder, Boulder, CO, United StatesBioFrontiers Institute, University of Colorado Boulder, Boulder, CO, United StatesPhenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are critical environmental cues that influence phenotypic plasticity and stability. Furthermore, an exposure to a prior mechanical signal has been demonstrated to play a fundamental role in modulating phenotypic changes that persist even after the mechanical stimulus is removed, creating stable mechanical memories. In this mini review, our objective is to highlight how the mechanical environment alters both phenotypic plasticity and stable memories through changes in chromatin architecture, mainly focusing on examples in cardiac tissue. We first explore how cell phenotypic plasticity is modulated in response to changes in the mechanical environment, and then connect the changes in phenotypic plasticity to changes in chromatin architecture that reflect short-term and long-term memories. Finally, we discuss how elucidating the mechanisms behind mechanically induced chromatin architecture that lead to cell adaptations and retention of stable mechanical memories could uncover treatment methods to prevent mal-adaptive permanent disease states.https://www.frontiersin.org/articles/10.3389/fcell.2023.1084759/fullcellular plasticitymechanotransductionmechanical memorychromatinepigenetics |
| spellingShingle | Adrienne K. Scott Michael Rafuse Corey P. Neu Corey P. Neu Corey P. Neu Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory Frontiers in Cell and Developmental Biology cellular plasticity mechanotransduction mechanical memory chromatin epigenetics |
| title | Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory |
| title_full | Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory |
| title_fullStr | Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory |
| title_full_unstemmed | Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory |
| title_short | Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory |
| title_sort | mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory |
| topic | cellular plasticity mechanotransduction mechanical memory chromatin epigenetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1084759/full |
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