Influence of probucol on cholesterol and lipoprotein metabolism in man.
The mechanisms for the hypocholesterolemic action of probucol were examined in 17 patients with various levels of plasma cholesterol and triglycerides (TG). All the patients were studied on a metabolic ward. The first period of 6 weeks was for control. Thereafter, probucol was started, and after 2–6...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1984-08-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520377415 |
| _version_ | 1818741345929396224 |
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| author | Y A Kesäniemi S M Grundy |
| author_facet | Y A Kesäniemi S M Grundy |
| author_sort | Y A Kesäniemi |
| collection | DOAJ |
| description | The mechanisms for the hypocholesterolemic action of probucol were examined in 17 patients with various levels of plasma cholesterol and triglycerides (TG). All the patients were studied on a metabolic ward. The first period of 6 weeks was for control. Thereafter, probucol was started, and after 2–6 months of drug treatment, the patients were readmitted for another 6-week period for a repeat study. During treatment with probucol, the cholesterol decreased in total plasma by an average of 12%, in low density lipoproteins (LDL) by 11%, and in high density lipoproteins (HDL) by 9%. The TG in total plasma and in very low density lipoproteins (VLDL) remained unchanged during probucol treatment. Turnover of low density lipoprotein apoprotein (apoLDL) was estimated following injection of 125I-labeled apoLDL. Probucol increased the fractional catabolic rate (FCR) for apoLDL by an average of 23%, but did not change apoLDL synthesis. The drug produced no consistent changes in fecal excretion of cholesterol (neutral steroids) and bile acids, in cholesterol absorption, in lipid composition of gallbladder bile, in biliary secretion of cholesterol and bile acids, or in the activities of lipoprotein lipase and hepatic lipase. These data show that probucol lowers LDL by increasing its catabolism. This effect appears to be independent of any changes in metabolism of cholesterol or bile acids. |
| first_indexed | 2024-12-18T01:55:09Z |
| format | Article |
| id | doaj.art-01713bbca65d4bd4be3d85ec5d626539 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-18T01:55:09Z |
| publishDate | 1984-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-01713bbca65d4bd4be3d85ec5d6265392022-12-21T21:24:55ZengElsevierJournal of Lipid Research0022-22751984-08-01258780790Influence of probucol on cholesterol and lipoprotein metabolism in man.Y A KesäniemiS M GrundyThe mechanisms for the hypocholesterolemic action of probucol were examined in 17 patients with various levels of plasma cholesterol and triglycerides (TG). All the patients were studied on a metabolic ward. The first period of 6 weeks was for control. Thereafter, probucol was started, and after 2–6 months of drug treatment, the patients were readmitted for another 6-week period for a repeat study. During treatment with probucol, the cholesterol decreased in total plasma by an average of 12%, in low density lipoproteins (LDL) by 11%, and in high density lipoproteins (HDL) by 9%. The TG in total plasma and in very low density lipoproteins (VLDL) remained unchanged during probucol treatment. Turnover of low density lipoprotein apoprotein (apoLDL) was estimated following injection of 125I-labeled apoLDL. Probucol increased the fractional catabolic rate (FCR) for apoLDL by an average of 23%, but did not change apoLDL synthesis. The drug produced no consistent changes in fecal excretion of cholesterol (neutral steroids) and bile acids, in cholesterol absorption, in lipid composition of gallbladder bile, in biliary secretion of cholesterol and bile acids, or in the activities of lipoprotein lipase and hepatic lipase. These data show that probucol lowers LDL by increasing its catabolism. This effect appears to be independent of any changes in metabolism of cholesterol or bile acids.http://www.sciencedirect.com/science/article/pii/S0022227520377415 |
| spellingShingle | Y A Kesäniemi S M Grundy Influence of probucol on cholesterol and lipoprotein metabolism in man. Journal of Lipid Research |
| title | Influence of probucol on cholesterol and lipoprotein metabolism in man. |
| title_full | Influence of probucol on cholesterol and lipoprotein metabolism in man. |
| title_fullStr | Influence of probucol on cholesterol and lipoprotein metabolism in man. |
| title_full_unstemmed | Influence of probucol on cholesterol and lipoprotein metabolism in man. |
| title_short | Influence of probucol on cholesterol and lipoprotein metabolism in man. |
| title_sort | influence of probucol on cholesterol and lipoprotein metabolism in man |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520377415 |
| work_keys_str_mv | AT yakesaniemi influenceofprobucoloncholesterolandlipoproteinmetabolisminman AT smgrundy influenceofprobucoloncholesterolandlipoproteinmetabolisminman |