Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore
Background: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease. Objective: We report the profile and outcome of 100 cases of BP seen at our center. Patients and Methods: This was a retrospective study of patients with BP seen at Changi General Hospital, Singapore f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Dermatology and Dermatologic Surgery |
| Subjects: | |
| Online Access: | http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2018;volume=22;issue=1;spage=12;epage=15;aulast=Tan |
| _version_ | 1818197898674831360 |
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| author | Siew-Kiang Tan Yong-Kwang Tay |
| author_facet | Siew-Kiang Tan Yong-Kwang Tay |
| author_sort | Siew-Kiang Tan |
| collection | DOAJ |
| description | Background: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease. Objective: We report the profile and outcome of 100 cases of BP seen at our center. Patients and Methods: This was a retrospective study of patients with BP seen at Changi General Hospital, Singapore from 2004 to 2012. Results: There were 57 female and 43 male patients. Other than the usual comorbidities such as diabetes mellitus and neurological diseases, there were a high incidence of osteoporosis (29%), hypothyroidism (6%), malignancy (6%), and hepatitis B carrier (3%). Peripheral blood eosinophilia is seen in almost half of the patients. The study results showed the higher sensitivity of direct immunofluorescence (93.5%) as compared to indirect immunofluorescence (89.1%). Topical and systemic corticosteroids were the standard treatment (96%). The duration to remission ranged from 2 weeks to 34 months, with a mean age of 7 months. Doxycycline and nicotinamide were effective for localized BP. The mortality rate was 35%. Conclusion: In Singapore, BP is associated with significant morbidity and mortality. High mortality of BP is related to the advanced age of the patients, associated medical conditions and complications from the treatment. |
| first_indexed | 2024-12-12T01:57:18Z |
| format | Article |
| id | doaj.art-0171c9c92b5544c3894f9eca4a6af686 |
| institution | Directory Open Access Journal |
| issn | 2352-2410 2352-2429 |
| language | English |
| last_indexed | 2024-12-12T01:57:18Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dermatology and Dermatologic Surgery |
| spelling | doaj.art-0171c9c92b5544c3894f9eca4a6af6862022-12-22T00:42:18ZengWolters Kluwer Medknow PublicationsJournal of Dermatology and Dermatologic Surgery2352-24102352-24292018-01-01221121510.4103/jdds.jdds_1_18Bullous pemphigoid: Profile and outcome in a series of 100 cases in SingaporeSiew-Kiang TanYong-Kwang TayBackground: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease. Objective: We report the profile and outcome of 100 cases of BP seen at our center. Patients and Methods: This was a retrospective study of patients with BP seen at Changi General Hospital, Singapore from 2004 to 2012. Results: There were 57 female and 43 male patients. Other than the usual comorbidities such as diabetes mellitus and neurological diseases, there were a high incidence of osteoporosis (29%), hypothyroidism (6%), malignancy (6%), and hepatitis B carrier (3%). Peripheral blood eosinophilia is seen in almost half of the patients. The study results showed the higher sensitivity of direct immunofluorescence (93.5%) as compared to indirect immunofluorescence (89.1%). Topical and systemic corticosteroids were the standard treatment (96%). The duration to remission ranged from 2 weeks to 34 months, with a mean age of 7 months. Doxycycline and nicotinamide were effective for localized BP. The mortality rate was 35%. Conclusion: In Singapore, BP is associated with significant morbidity and mortality. High mortality of BP is related to the advanced age of the patients, associated medical conditions and complications from the treatment.http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2018;volume=22;issue=1;spage=12;epage=15;aulast=Tanbullous pemphigoidoutcomesingapore |
| spellingShingle | Siew-Kiang Tan Yong-Kwang Tay Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore Journal of Dermatology and Dermatologic Surgery bullous pemphigoid outcome singapore |
| title | Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore |
| title_full | Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore |
| title_fullStr | Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore |
| title_full_unstemmed | Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore |
| title_short | Bullous pemphigoid: Profile and outcome in a series of 100 cases in Singapore |
| title_sort | bullous pemphigoid profile and outcome in a series of 100 cases in singapore |
| topic | bullous pemphigoid outcome singapore |
| url | http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2018;volume=22;issue=1;spage=12;epage=15;aulast=Tan |
| work_keys_str_mv | AT siewkiangtan bullouspemphigoidprofileandoutcomeinaseriesof100casesinsingapore AT yongkwangtay bullouspemphigoidprofileandoutcomeinaseriesof100casesinsingapore |