Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation
Ahmed Salman,1 Mohamed Aon,1 Amr Hussein,2 Mohamed Salman,3 Mohamed Tourky,4 Ahmed Mahmoud,5 Feras Aljarad,6 Mohamed Elkaseer,7 Hossam El-Din Shaaban,8 Ahmed Moustafa,9 Ahmed El-Mikkawy,10 Nahla Gaballa,11 Heba Abdallah,12 Zaky Ftouh Zaky Rashed,13,14 Hesham Elkassar1 1Internal Medicine Department,...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-09-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impact-of-hypothyroidism-on-patients-with-hepatocellular-carcinoma-und-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1831753812054900736 |
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| author | Salman A Aon M Hussein A Salman M Tourky M Mahmoud A Aljarad F Elkaseer M Shaaban HE Moustafa A El-Mikkawy A Gaballa N Abdallah H Zaky Rashed ZF Elkassar H |
| author_facet | Salman A Aon M Hussein A Salman M Tourky M Mahmoud A Aljarad F Elkaseer M Shaaban HE Moustafa A El-Mikkawy A Gaballa N Abdallah H Zaky Rashed ZF Elkassar H |
| author_sort | Salman A |
| collection | DOAJ |
| description | Ahmed Salman,1 Mohamed Aon,1 Amr Hussein,2 Mohamed Salman,3 Mohamed Tourky,4 Ahmed Mahmoud,5 Feras Aljarad,6 Mohamed Elkaseer,7 Hossam El-Din Shaaban,8 Ahmed Moustafa,9 Ahmed El-Mikkawy,10 Nahla Gaballa,11 Heba Abdallah,12 Zaky Ftouh Zaky Rashed,13,14 Hesham Elkassar1 1Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Department of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UK; 5Senior Clinical Fellow, Great Western Hospital NHS Foundation Trust, Swindon, UK; 6Lewisham and Greenwich NHS Trust, Lewisham, London, UK; 7General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 8Hepatology and Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 9Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt; 10Hepatology and Gastroenterology Department, Theodor Bilharz Research Institute, Cairo, Egypt; 11Anesthesiology and Intensive Care Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt; 12Clinical Pathology Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt; 13Anesthesiology and Intensive Care Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 14Department of Anesthesia, College of Applied Sciences, Almaarefa university, Ad Diriyah, Riyadh, Saudi ArabiaCorrespondence: Ahmed SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, EgyptTel +20 1000468664Email awea844@gmail.comBackground: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT).Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS).Results: Euthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p< 0.001) or the donor (p< 0.001), hypothyroidism (p=0.008), HBV (p=0.029), larger tumor size (p=0.023), and defective Milan criteria (p=0.022). On multivariate analysis, the age of the patients and donors was the independent factor affecting OS. On univariate analysis, DFS was negatively affected by older age of the patients (p < 0.001) or the donor (p=0.005), hypothyroidism (p=0.005), HBV (p=0.019), larger tumor size (p=0.023), and defective Milan criteria (p=0.020). On multivariate analysis, the age of the patients, thyroid status, and Milan criteria were the independent factors affecting DFS.Conclusion: Hypothyroidism is a risk factor for worse outcomes in HCC patients after liver transplantation.Keywords: hypothyroidism, hepatocellular carcinoma, liver transplantation |
| first_indexed | 2024-12-21T23:28:19Z |
| format | Article |
| id | doaj.art-01723e7173f64c32a2c351a4b4d2f8a1 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-21T23:28:19Z |
| publishDate | 2021-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-01723e7173f64c32a2c351a4b4d2f8a12022-12-21T18:46:34ZengDove Medical PressInternational Journal of General Medicine1178-70742021-09-01Volume 145711571868861Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver TransplantationSalman AAon MHussein ASalman MTourky MMahmoud AAljarad FElkaseer MShaaban HEMoustafa AEl-Mikkawy AGaballa NAbdallah HZaky Rashed ZFElkassar HAhmed Salman,1 Mohamed Aon,1 Amr Hussein,2 Mohamed Salman,3 Mohamed Tourky,4 Ahmed Mahmoud,5 Feras Aljarad,6 Mohamed Elkaseer,7 Hossam El-Din Shaaban,8 Ahmed Moustafa,9 Ahmed El-Mikkawy,10 Nahla Gaballa,11 Heba Abdallah,12 Zaky Ftouh Zaky Rashed,13,14 Hesham Elkassar1 1Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 3General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 4Department of Surgery, Great Western Hospitals NHS Foundation Trust, Swindon, UK; 5Senior Clinical Fellow, Great Western Hospital NHS Foundation Trust, Swindon, UK; 6Lewisham and Greenwich NHS Trust, Lewisham, London, UK; 7General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 8Hepatology and Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt; 9Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt; 10Hepatology and Gastroenterology Department, Theodor Bilharz Research Institute, Cairo, Egypt; 11Anesthesiology and Intensive Care Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt; 12Clinical Pathology Department, National Liver Institute, Menoufia University, Shibin El Kom, Egypt; 13Anesthesiology and Intensive Care Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt; 14Department of Anesthesia, College of Applied Sciences, Almaarefa university, Ad Diriyah, Riyadh, Saudi ArabiaCorrespondence: Ahmed SalmanInternal Medicine Department, Faculty of Medicine, Cairo University, EgyptTel +20 1000468664Email awea844@gmail.comBackground: This work endeavored to explore the effect of hypothyroidism on mortality in subjects with HCC who underwent living-donor liver transplantation (LDLT).Methods: This prospective study included 107 patients with HCC subjected to LDLT, divided into hypothyroid group (n=53) and euthyroid group (n=54). The primary objectives were overall and disease-free survival (DFS).Results: Euthyroid and hypothyroid groups were comparable in all baseline characteristics except the age of patients. Overall survival (OS) of the whole group at 48 months was 68.8%, while the DFS was 60.2%. On univariate analysis, OS was negatively affected by the older age of the patients (p< 0.001) or the donor (p< 0.001), hypothyroidism (p=0.008), HBV (p=0.029), larger tumor size (p=0.023), and defective Milan criteria (p=0.022). On multivariate analysis, the age of the patients and donors was the independent factor affecting OS. On univariate analysis, DFS was negatively affected by older age of the patients (p < 0.001) or the donor (p=0.005), hypothyroidism (p=0.005), HBV (p=0.019), larger tumor size (p=0.023), and defective Milan criteria (p=0.020). On multivariate analysis, the age of the patients, thyroid status, and Milan criteria were the independent factors affecting DFS.Conclusion: Hypothyroidism is a risk factor for worse outcomes in HCC patients after liver transplantation.Keywords: hypothyroidism, hepatocellular carcinoma, liver transplantationhttps://www.dovepress.com/impact-of-hypothyroidism-on-patients-with-hepatocellular-carcinoma-und-peer-reviewed-fulltext-article-IJGMhypothyroidism & hepatocellular carcinoma & liver transplantation |
| spellingShingle | Salman A Aon M Hussein A Salman M Tourky M Mahmoud A Aljarad F Elkaseer M Shaaban HE Moustafa A El-Mikkawy A Gaballa N Abdallah H Zaky Rashed ZF Elkassar H Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation International Journal of General Medicine hypothyroidism & hepatocellular carcinoma & liver transplantation |
| title | Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation |
| title_full | Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation |
| title_fullStr | Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation |
| title_full_unstemmed | Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation |
| title_short | Impact of Hypothyroidism on Patients with Hepatocellular Carcinoma Undergoing Liver Transplantation |
| title_sort | impact of hypothyroidism on patients with hepatocellular carcinoma undergoing liver transplantation |
| topic | hypothyroidism & hepatocellular carcinoma & liver transplantation |
| url | https://www.dovepress.com/impact-of-hypothyroidism-on-patients-with-hepatocellular-carcinoma-und-peer-reviewed-fulltext-article-IJGM |
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