Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses

Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses

The naturally occurring betulinic acid (BA) and its derivative NVX-207 induce apoptosis in equine melanoma cells in vitro. After topical application, high concentrations of the substances can be reached in healthy equine skin. With the aim to investigate the effect and safety of topically applied BA...

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Bibliographic Details
Main Authors: Lisa A. Weber, Julien Delarocque, Karsten Feige, Manfred Kietzmann, Jutta Kalbitz, Jessica Meißner, Reinhard Paschke, Jessika-M. V. Cavalleri
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Animals
Subjects:
equine melanocytic tumor
horse
oncology
skin neoplasia
topical drug
triterpenoids
Online Access:https://www.mdpi.com/2076-2615/11/11/3250

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