Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report
We describe an unusual case of hyperacute hepatic failure following general anesthesia in a patient receiving a simultaneous kidney-pancreas transplant. Despite an aggressive evaluation of structural, immunological, viral, and toxicological causes, a definitive cause could not be elucidated. The pat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-09-01
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| Series: | Brazilian Journal of Anesthesiology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001418300320 |
| _version_ | 1828380335459532800 |
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| author | Jimmy L. Moss Benjamin W. Brown Sher-Lu Pai Klaus D. Torp Stephen Aniskevich |
| author_facet | Jimmy L. Moss Benjamin W. Brown Sher-Lu Pai Klaus D. Torp Stephen Aniskevich |
| author_sort | Jimmy L. Moss |
| collection | DOAJ |
| description | We describe an unusual case of hyperacute hepatic failure following general anesthesia in a patient receiving a simultaneous kidney-pancreas transplant. Despite an aggressive evaluation of structural, immunological, viral, and toxicological causes, a definitive cause could not be elucidated. The patient required a liver transplant and suffered a protracted hospital course. We discuss the potential causes of fulminant hepatic failure and the perioperative anesthesia management of her subsequent liver transplantation. Resumo: Descrevemos um caso incomum de insuficiência hepática hiperaguda após a anestesia geral em uma paciente que recebeu um transplante simultâneo de rim-pâncreas. Apesar de uma avaliação agressiva das causas estruturais, imunológicas, virais e toxicológicas, uma causa definitiva não pôde ser identificada. A paciente precisou de um transplante de fígado que resultou em prolongamento da internação hospitalar. Discutimos as potenciais causas da insuficiência hepática fulminante e o manejo da anestesia no período perioperatório de seu subsequente transplante de fígado. Keywords: Liver failure, Kidney-pancreas transplant, Volatile agents, Liver transplant, Drug reaction, Isoflurane toxicity, Adverse drug reaction, Inhalational anesthesia, Palavras-chave: Insuficiência hepática, Transplante de rim-pâncreas, Agentes voláteis, Transplante de fígado, Reação medicamentosa, Toxicidade por isoflurano, Reação medicamentosa adversa, Anestesia inalatória |
| first_indexed | 2024-12-10T03:56:18Z |
| format | Article |
| id | doaj.art-01752b22b3b543a59535a3b0fadbe00b |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-12-10T03:56:18Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-01752b22b3b543a59535a3b0fadbe00b2022-12-22T02:03:07ZengElsevierBrazilian Journal of Anesthesiology0104-00142018-09-01685535538Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case reportJimmy L. Moss0Benjamin W. Brown1Sher-Lu Pai2Klaus D. Torp3Stephen Aniskevich4Mayo Clinic Florida, Division of Hepatobiliary and Transplant Anesthesia, Department of Anesthesiology, Jacksonville, United StatesMayo Clinic Florida, Division of Hepatobiliary and Transplant Anesthesia, Department of Anesthesiology, Jacksonville, United StatesMayo Clinic Florida, Division of Hepatobiliary and Transplant Anesthesia, Department of Anesthesiology, Jacksonville, United StatesMayo Clinic Florida, Division of Hepatobiliary and Transplant Anesthesia, Department of Anesthesiology, Jacksonville, United StatesCorresponding author.; Mayo Clinic Florida, Division of Hepatobiliary and Transplant Anesthesia, Department of Anesthesiology, Jacksonville, United StatesWe describe an unusual case of hyperacute hepatic failure following general anesthesia in a patient receiving a simultaneous kidney-pancreas transplant. Despite an aggressive evaluation of structural, immunological, viral, and toxicological causes, a definitive cause could not be elucidated. The patient required a liver transplant and suffered a protracted hospital course. We discuss the potential causes of fulminant hepatic failure and the perioperative anesthesia management of her subsequent liver transplantation. Resumo: Descrevemos um caso incomum de insuficiência hepática hiperaguda após a anestesia geral em uma paciente que recebeu um transplante simultâneo de rim-pâncreas. Apesar de uma avaliação agressiva das causas estruturais, imunológicas, virais e toxicológicas, uma causa definitiva não pôde ser identificada. A paciente precisou de um transplante de fígado que resultou em prolongamento da internação hospitalar. Discutimos as potenciais causas da insuficiência hepática fulminante e o manejo da anestesia no período perioperatório de seu subsequente transplante de fígado. Keywords: Liver failure, Kidney-pancreas transplant, Volatile agents, Liver transplant, Drug reaction, Isoflurane toxicity, Adverse drug reaction, Inhalational anesthesia, Palavras-chave: Insuficiência hepática, Transplante de rim-pâncreas, Agentes voláteis, Transplante de fígado, Reação medicamentosa, Toxicidade por isoflurano, Reação medicamentosa adversa, Anestesia inalatóriahttp://www.sciencedirect.com/science/article/pii/S0104001418300320 |
| spellingShingle | Jimmy L. Moss Benjamin W. Brown Sher-Lu Pai Klaus D. Torp Stephen Aniskevich Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report Brazilian Journal of Anesthesiology |
| title | Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report |
| title_full | Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report |
| title_fullStr | Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report |
| title_full_unstemmed | Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report |
| title_short | Fulminant hepatic failure after simultaneous kidney-pancreas transplantation: a case report |
| title_sort | fulminant hepatic failure after simultaneous kidney pancreas transplantation a case report |
| url | http://www.sciencedirect.com/science/article/pii/S0104001418300320 |
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