Prolonged Voluntary Running Negatively Affects Survival and Disease Prognosis of Male SOD1G93A Low-Copy Transgenic Mice

Prolonged Voluntary Running Negatively Affects Survival and Disease Prognosis of Male SOD1G93A Low-Copy Transgenic Mice

Amyotrophic Lateral Sclerosis (ALS) is a disease in which physical activity plays a controversial role. Epidemiological studies indicate an association between intense exercise and risk of developing ALS. To study the impact of physical activity on ALS, mouse models rely mostly on forced exercise. I...

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Bibliographic Details
Main Authors: Luciana Garbugino, Elisabetta Golini, Alessandro Giuliani, Silvia Mandillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
ALS
exercise
running wheels
sex differences
rotarod
Principal Component Analysis
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00275/full

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