Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma
α-Mangostin, a xanthone derivative from the pericarp of mangosteen, exerts both anti-proliferative and cytotoxic effects on various cancers. However, the effect of α-mangostin on hepatocellular carcinoma (HCC) cells has not yet been fully determined. Therefore, the present study investigated the ant...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616302249 |
| _version_ | 1818409964578799616 |
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| author | Nan Cai Shu-Juan Xie Dong-Bo Qiu Chang-Chang Jia Cong Du Wei Liu Jia-Jie Chen Qi Zhang |
| author_facet | Nan Cai Shu-Juan Xie Dong-Bo Qiu Chang-Chang Jia Cong Du Wei Liu Jia-Jie Chen Qi Zhang |
| author_sort | Nan Cai |
| collection | DOAJ |
| description | α-Mangostin, a xanthone derivative from the pericarp of mangosteen, exerts both anti-proliferative and cytotoxic effects on various cancers. However, the effect of α-mangostin on hepatocellular carcinoma (HCC) cells has not yet been fully determined. Therefore, the present study investigated the anti-proliferative effect of α-mangostin on HCC cells. α-Mangostin inhibited the proliferation of HCC and malignantly transformed hepatic cells. In addition, α-mangostin induced G0/G1 phase cell cycle arrest. Furthermore, α-mangostin also reversed doxorubicin-resistance in the HCC cells induced by IL-6. Moreover, the percentage of CD133, CD44 and EpCAM positive stem-like HCC cells treated with α-mangostin was reduced. The expression of key stemness transcription factors, such as Bmi-1, c-Myc and Nanog, were also suppressed following α-mangostin treatment. In conclusion, α-mangostin has been shown to have anti-proliferative effects in HCC cells and malignantly transformed hepatic cells. This work discovered the potential effect of α-mangostin in HCC prevention and treatment. |
| first_indexed | 2024-12-14T10:07:59Z |
| format | Article |
| id | doaj.art-0177b4c5d9c24845a6fd7fc6a7cf088c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T10:07:59Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0177b4c5d9c24845a6fd7fc6a7cf088c2022-12-21T23:07:05ZengElsevierJournal of Functional Foods1756-46462016-10-0126309318Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinomaNan Cai0Shu-Juan Xie1Dong-Bo Qiu2Chang-Chang Jia3Cong Du4Wei Liu5Jia-Jie Chen6Qi Zhang7Vaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, ChinaVaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, ChinaVaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, ChinaVaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, ChinaVaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, ChinaGuangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, ChinaInstitute of Molecular Medicine, Health Science Centre, Shenzhen University, Shenzhen 518060, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China; Corresponding author. Institute of Molecular Medicine, Health Science Centre, Shenzhen University, Nanhai Ave 3688, Shenzhen 518060, China. Fax: +86755286671906.Vaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China; Corresponding author. Vaccine Research Institute of Sun Yat-sen University, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China. Fax: +862087585295.α-Mangostin, a xanthone derivative from the pericarp of mangosteen, exerts both anti-proliferative and cytotoxic effects on various cancers. However, the effect of α-mangostin on hepatocellular carcinoma (HCC) cells has not yet been fully determined. Therefore, the present study investigated the anti-proliferative effect of α-mangostin on HCC cells. α-Mangostin inhibited the proliferation of HCC and malignantly transformed hepatic cells. In addition, α-mangostin induced G0/G1 phase cell cycle arrest. Furthermore, α-mangostin also reversed doxorubicin-resistance in the HCC cells induced by IL-6. Moreover, the percentage of CD133, CD44 and EpCAM positive stem-like HCC cells treated with α-mangostin was reduced. The expression of key stemness transcription factors, such as Bmi-1, c-Myc and Nanog, were also suppressed following α-mangostin treatment. In conclusion, α-mangostin has been shown to have anti-proliferative effects in HCC cells and malignantly transformed hepatic cells. This work discovered the potential effect of α-mangostin in HCC prevention and treatment.http://www.sciencedirect.com/science/article/pii/S1756464616302249α-MangostinHepatocellular carcinomaCancer preventionCancer treatment |
| spellingShingle | Nan Cai Shu-Juan Xie Dong-Bo Qiu Chang-Chang Jia Cong Du Wei Liu Jia-Jie Chen Qi Zhang Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma Journal of Functional Foods α-Mangostin Hepatocellular carcinoma Cancer prevention Cancer treatment |
| title | Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma |
| title_full | Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma |
| title_fullStr | Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma |
| title_full_unstemmed | Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma |
| title_short | Potential effects of α-mangostin in the prevention and treatment of hepatocellular carcinoma |
| title_sort | potential effects of α mangostin in the prevention and treatment of hepatocellular carcinoma |
| topic | α-Mangostin Hepatocellular carcinoma Cancer prevention Cancer treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616302249 |
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