The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease
<p>Abstract</p> <p>Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allow them to efficiently inhibit target enzymes, such as...
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| Format: | Article |
| Language: | English |
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BMC
2000-08-01
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| Series: | Respiratory Research |
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| Online Access: | http://dx.doi.org/10.1186/rr18 |
| _version_ | 1818084046449672192 |
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| author | Sallenave Jean-Michel |
| author_facet | Sallenave Jean-Michel |
| author_sort | Sallenave Jean-Michel |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allow them to efficiently inhibit target enzymes, such as neutrophil elastase, released into the interstitium. Historically, in the lung, these inhibitors were first purified from secretions of patients with chronic obstructive pulmonary disease and cystic fibrosis. This suggested that they might be important in controlling excessive neutrophil elastase release in these pathologies. They are upregulated by 'alarm signals' such as bacterial lipopolysaccharides, and cytokines such as interleukin-1 and tumor necrosis factor and have been shown to be active against Gram-positive and Gram-negative bacteria, so that they have joined the growing list of antimicrobial 'defensin-like' peptides produced by the lung. Their site of synthesis and presumed functions make them very attractive candidates as potential therapeutic agents under conditions in which the excessive release of elastase by neutrophils might be detrimental. Because of its natural tropism for the lung, the use of adenovirus-mediated gene transfer is extremely promising in such applications.</p> |
| first_indexed | 2024-12-10T19:47:40Z |
| format | Article |
| id | doaj.art-01784a5913ab4d7d8b063c13458bcfa2 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-10T19:47:40Z |
| publishDate | 2000-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-01784a5913ab4d7d8b063c13458bcfa22022-12-22T01:35:51ZengBMCRespiratory Research1465-99212000-08-0112879210.1186/rr18The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung diseaseSallenave Jean-Michel<p>Abstract</p> <p>Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allow them to efficiently inhibit target enzymes, such as neutrophil elastase, released into the interstitium. Historically, in the lung, these inhibitors were first purified from secretions of patients with chronic obstructive pulmonary disease and cystic fibrosis. This suggested that they might be important in controlling excessive neutrophil elastase release in these pathologies. They are upregulated by 'alarm signals' such as bacterial lipopolysaccharides, and cytokines such as interleukin-1 and tumor necrosis factor and have been shown to be active against Gram-positive and Gram-negative bacteria, so that they have joined the growing list of antimicrobial 'defensin-like' peptides produced by the lung. Their site of synthesis and presumed functions make them very attractive candidates as potential therapeutic agents under conditions in which the excessive release of elastase by neutrophils might be detrimental. Because of its natural tropism for the lung, the use of adenovirus-mediated gene transfer is extremely promising in such applications.</p>http://dx.doi.org/10.1186/rr18adenoviruselafin/elastase-specific inhibitor/skin-derived antileukoproteaseelastaseinflammationsecretory leukocyte proteinase inhibitor |
| spellingShingle | Sallenave Jean-Michel The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease Respiratory Research adenovirus elafin/elastase-specific inhibitor/skin-derived antileukoprotease elastase inflammation secretory leukocyte proteinase inhibitor |
| title | The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease |
| title_full | The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease |
| title_fullStr | The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease |
| title_full_unstemmed | The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease |
| title_short | The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease |
| title_sort | role of secretory leukocyte proteinase inhibitor and elafin elastase specific inhibitor skin derived antileukoprotease as alarm antiproteinases in inflammatory lung disease |
| topic | adenovirus elafin/elastase-specific inhibitor/skin-derived antileukoprotease elastase inflammation secretory leukocyte proteinase inhibitor |
| url | http://dx.doi.org/10.1186/rr18 |
| work_keys_str_mv | AT sallenavejeanmichel theroleofsecretoryleukocyteproteinaseinhibitorandelafinelastasespecificinhibitorskinderivedantileukoproteaseasalarmantiproteinasesininflammatorylungdisease AT sallenavejeanmichel roleofsecretoryleukocyteproteinaseinhibitorandelafinelastasespecificinhibitorskinderivedantileukoproteaseasalarmantiproteinasesininflammatorylungdisease |