Nitric oxide mediates the blood pressure response to mental stress in humans
OBJECTIVE: Nitric oxide (NO) regulates arterial pressure by modulating peripheral vascular tone and sympathetic vasoconstrictor outflow. NO synthesis is impaired in several major cardiovascular disease states. Loss of NO-induced vasodilator tone and restraint on sympathetic outflow could res...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2012-07-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1517 |
| _version_ | 1797979573757935616 |
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| author | Lionel Trueb Mattia Lepori Hervé Duplain Urs Scherrer Claudio Sartori |
| author_facet | Lionel Trueb Mattia Lepori Hervé Duplain Urs Scherrer Claudio Sartori |
| author_sort | Lionel Trueb |
| collection | DOAJ |
| description |
OBJECTIVE: Nitric oxide (NO) regulates arterial pressure by modulating peripheral vascular tone and sympathetic vasoconstrictor outflow. NO synthesis is impaired in several major cardiovascular disease states. Loss of NO-induced vasodilator tone and restraint on sympathetic outflow could result in exaggerated pressor responses to mental stress.
METHODS: We, therefore, compared the sympathetic (muscle sympathetic nerve activity) and haemodynamic responses to mental stress performed during saline infusion and systemic inhibition of NO-synthase by NG-monomethyl-L-arginine (L-NMMA) infusion.
RESULTS: The major finding was that mental stress which during saline infusion increased sympathetic nerve activity by ~50 percent and mean arterial pressure by ~15 percent had no detectable sympathoexcitatory and pressor effect during L-NMMA infusion. These findings were not related to a generalised impairment of the haemodynamic and/or sympathetic responsiveness by L-NMMA, since the pressor and sympathetic nerve responses to immersion of the hand in ice water were preserved during L-NMMA infusion.
CONCLUSION: Mental stress causes pressor and sympathoexcitatory effects in humans that are mediated by NO. These findings are consistent with the new concept that, in contrast to what has been generally assumed, under some circumstances, NO has a blood pressure raising action in vivo.
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| first_indexed | 2024-04-11T05:41:56Z |
| format | Article |
| id | doaj.art-0178b51106fc4622b61f663ce565b89f |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-11T05:41:56Z |
| publishDate | 2012-07-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-0178b51106fc4622b61f663ce565b89f2022-12-22T04:42:31ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972012-07-01142272810.4414/smw.2012.13627Nitric oxide mediates the blood pressure response to mental stress in humansLionel TruebMattia LeporiHervé DuplainUrs ScherrerClaudio Sartori OBJECTIVE: Nitric oxide (NO) regulates arterial pressure by modulating peripheral vascular tone and sympathetic vasoconstrictor outflow. NO synthesis is impaired in several major cardiovascular disease states. Loss of NO-induced vasodilator tone and restraint on sympathetic outflow could result in exaggerated pressor responses to mental stress. METHODS: We, therefore, compared the sympathetic (muscle sympathetic nerve activity) and haemodynamic responses to mental stress performed during saline infusion and systemic inhibition of NO-synthase by NG-monomethyl-L-arginine (L-NMMA) infusion. RESULTS: The major finding was that mental stress which during saline infusion increased sympathetic nerve activity by ~50 percent and mean arterial pressure by ~15 percent had no detectable sympathoexcitatory and pressor effect during L-NMMA infusion. These findings were not related to a generalised impairment of the haemodynamic and/or sympathetic responsiveness by L-NMMA, since the pressor and sympathetic nerve responses to immersion of the hand in ice water were preserved during L-NMMA infusion. CONCLUSION: Mental stress causes pressor and sympathoexcitatory effects in humans that are mediated by NO. These findings are consistent with the new concept that, in contrast to what has been generally assumed, under some circumstances, NO has a blood pressure raising action in vivo. https://www.smw.ch/index.php/smw/article/view/1517autonomic nervous systemHypertensionmental stressNitric oxidevasoconstriction |
| spellingShingle | Lionel Trueb Mattia Lepori Hervé Duplain Urs Scherrer Claudio Sartori Nitric oxide mediates the blood pressure response to mental stress in humans Swiss Medical Weekly autonomic nervous system Hypertension mental stress Nitric oxide vasoconstriction |
| title | Nitric oxide mediates the blood pressure response to mental stress in humans |
| title_full | Nitric oxide mediates the blood pressure response to mental stress in humans |
| title_fullStr | Nitric oxide mediates the blood pressure response to mental stress in humans |
| title_full_unstemmed | Nitric oxide mediates the blood pressure response to mental stress in humans |
| title_short | Nitric oxide mediates the blood pressure response to mental stress in humans |
| title_sort | nitric oxide mediates the blood pressure response to mental stress in humans |
| topic | autonomic nervous system Hypertension mental stress Nitric oxide vasoconstriction |
| url | https://www.smw.ch/index.php/smw/article/view/1517 |
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