Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle>
The high seroprevalence of human herpesvirus type 8 (HHV-8) in moderate or severe cirrhotics appears to be associated with male sex, hepatitis B virus (HBV) infection, alcoholism, and disease severity. The status of HHV-8 infection in mild cirrhotics remains unclear. Plasma samples collected from 93...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-01-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2017.32 |
| _version_ | 1827809019373289472 |
|---|---|
| author | Kuo-Chih Tseng Ming-Nan Lin Tang-Yuan Chu Jen-Pi Tsai Cheng-Chuan Su |
| author_facet | Kuo-Chih Tseng Ming-Nan Lin Tang-Yuan Chu Jen-Pi Tsai Cheng-Chuan Su |
| author_sort | Kuo-Chih Tseng |
| collection | DOAJ |
| description | The high seroprevalence of human herpesvirus type 8 (HHV-8) in moderate or severe cirrhotics appears to be associated with male sex, hepatitis B virus (HBV) infection, alcoholism, and disease severity. The status of HHV-8 infection in mild cirrhotics remains unclear. Plasma samples collected from 93 mild cirrhotics and 93 age- and sex-matched healthy controls were analyzed for HHV-8 antibody and HHV-8 DNA. Mild cirrhotics had higher seropositivity for HHV-8 antibodies than healthy controls (P=0.0001). Univariate logistic regression analysis revealed that an age ≥55 years (odds ratio (OR) 2.88, P=0.02), hepatitis C virus (HCV) infection (OR 3.42, P=0.01), and hepatitis activity (OR 4.10, P=0.004) were associated with HHV-8 seropositivity in cirrhotics. Stepwise multivariate logistic regression analysis confirmed that age ≥55 years (adjusted OR (aOR) 1.92, P=0.04) and hepatitis activity (aOR 3.55, P=0.005) were independent factors. The rate of hepatitis activity was higher in HCV-infected than in HBV-infected patients (P<0.0001) and in women than in men (P=0.0001). Cirrhotics who were seropositive for HHV-8 or HCV or had hepatitis activity were significantly older (P=0.02, <0.0001 and <0.0001, respectively). Plasma samples from all participants were negative for HHV-8 DNA. HHV-8 antibody titers in mild cirrhotics also markedly exceeded those in controls (P<0.0001), as did those in patients ≥55 years old vs. younger patients (P=0.01), those in patients with vs. without HCV infection (P=0.0008), and those in patients with vs. without hepatitis activity (P=0.0005). Mild cirrhotics had high HHV-8 seroprevalence and HCV infection, and, in particular, old age and hepatitis activity were predictors.Emerging Microbes & Infections (2017) 6, e45; doi:10.1038/emi.2017.32; published online 7 June 2017 |
| first_indexed | 2024-03-11T22:37:30Z |
| format | Article |
| id | doaj.art-01795768ebbf44898e80683bea3f04f0 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T22:37:30Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-01795768ebbf44898e80683bea3f04f02023-09-22T12:08:35ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512017-01-01611610.1038/emi.2017.32Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle>Kuo-Chih Tseng0Ming-Nan Lin1Tang-Yuan Chu2Jen-Pi Tsai3Cheng-Chuan Su4School of MedicineTzu Chi University, Hualien 970, TaiwanSchool of MedicineTzu Chi University, Hualien 970, TaiwanInstitute of Medical SciencesTzu Chi University, Hualien 970, TaiwanSchool of MedicineTzu Chi University, Hualien 970, TaiwanSchool of MedicineTzu Chi University, Hualien 970, TaiwanThe high seroprevalence of human herpesvirus type 8 (HHV-8) in moderate or severe cirrhotics appears to be associated with male sex, hepatitis B virus (HBV) infection, alcoholism, and disease severity. The status of HHV-8 infection in mild cirrhotics remains unclear. Plasma samples collected from 93 mild cirrhotics and 93 age- and sex-matched healthy controls were analyzed for HHV-8 antibody and HHV-8 DNA. Mild cirrhotics had higher seropositivity for HHV-8 antibodies than healthy controls (P=0.0001). Univariate logistic regression analysis revealed that an age ≥55 years (odds ratio (OR) 2.88, P=0.02), hepatitis C virus (HCV) infection (OR 3.42, P=0.01), and hepatitis activity (OR 4.10, P=0.004) were associated with HHV-8 seropositivity in cirrhotics. Stepwise multivariate logistic regression analysis confirmed that age ≥55 years (adjusted OR (aOR) 1.92, P=0.04) and hepatitis activity (aOR 3.55, P=0.005) were independent factors. The rate of hepatitis activity was higher in HCV-infected than in HBV-infected patients (P<0.0001) and in women than in men (P=0.0001). Cirrhotics who were seropositive for HHV-8 or HCV or had hepatitis activity were significantly older (P=0.02, <0.0001 and <0.0001, respectively). Plasma samples from all participants were negative for HHV-8 DNA. HHV-8 antibody titers in mild cirrhotics also markedly exceeded those in controls (P<0.0001), as did those in patients ≥55 years old vs. younger patients (P=0.01), those in patients with vs. without HCV infection (P=0.0008), and those in patients with vs. without hepatitis activity (P=0.0005). Mild cirrhotics had high HHV-8 seroprevalence and HCV infection, and, in particular, old age and hepatitis activity were predictors.Emerging Microbes & Infections (2017) 6, e45; doi:10.1038/emi.2017.32; published online 7 June 2017https://www.tandfonline.com/doi/10.1038/emi.2017.32alcoholcirrhosisHBVHCVHHV-8 |
| spellingShingle | Kuo-Chih Tseng Ming-Nan Lin Tang-Yuan Chu Jen-Pi Tsai Cheng-Chuan Su Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle> Emerging Microbes and Infections alcohol cirrhosis HBV HCV HHV-8 |
| title | Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle> |
| title_full | Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle> |
| title_fullStr | Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle> |
| title_full_unstemmed | Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle> |
| title_short | Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis<subtitle>HHV-8 and mild cirrhosis</subtitle> |
| title_sort | predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis subtitle hhv 8 and mild cirrhosis subtitle |
| topic | alcohol cirrhosis HBV HCV HHV-8 |
| url | https://www.tandfonline.com/doi/10.1038/emi.2017.32 |
| work_keys_str_mv | AT kuochihtseng predictorsofseropositivityforhumanherpesvirustype8inpatientswithmildcirrhosissubtitlehhv8andmildcirrhosissubtitle AT mingnanlin predictorsofseropositivityforhumanherpesvirustype8inpatientswithmildcirrhosissubtitlehhv8andmildcirrhosissubtitle AT tangyuanchu predictorsofseropositivityforhumanherpesvirustype8inpatientswithmildcirrhosissubtitlehhv8andmildcirrhosissubtitle AT jenpitsai predictorsofseropositivityforhumanherpesvirustype8inpatientswithmildcirrhosissubtitlehhv8andmildcirrhosissubtitle AT chengchuansu predictorsofseropositivityforhumanherpesvirustype8inpatientswithmildcirrhosissubtitlehhv8andmildcirrhosissubtitle |