Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2

Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2

Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration. The aim of this work was to 1) simultaneously characterise the pharmacokinetic...

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Bibliographic Details
Main Authors: Hong-can Ren, Jian-guo Sun, Ji-ye A, Sheng-hua Gu, Jian Shi, Feng Shao, Hua Ai, Jing-wei Zhang, Ying Peng, Bei Yan, Qing Huang, Lin-sheng Liu, Yang Sai, Guang-ji Wang, Cheng-guang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
traditional Chinese medicine
ginsenosides
pharmacokinetics
deglycosylation
modelling and simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.804377/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.804377/full

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